Enhancing HOTAIR/MiR-10b Drives Normal Liver Stem Cells Toward a Tendency to Malignant Transformation Through Inducing Epithelial- to-Mesenchymal Transition

Previously, other groups and our team consistently have demonstrated that the possible origination of liver cancer stem cells (LCSCs) is the malignant transformation from liver normal stem cells (LNSCs). However, this complex and multi-step process is far from clear due to the accumulation of variou...

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Veröffentlicht in:	Rejuvenation research 2015-08, Vol.18 (4), p.332-340
Hauptverfasser:	Ye, Ping, Wang, Tao, Liu, Wei-hui, Li, Xiu-chuan, Tang, Li-jun, Tian, Fu-zhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Biomarkers - metabolism Cadherins - metabolism Carcinogenesis - genetics Carcinogenesis - pathology Cell Cycle - genetics Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Down-Regulation - genetics Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic Liver - pathology Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Original Articles Rats, Inbred F344 RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Stem Cells - metabolism Up-Regulation - genetics
Online-Zugang:	Volltext
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