Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes
Only a few studies have evaluated the long-term effects of nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and none have examined whether NAFLD improvement reduces T2DM incidence. We investigated the association between NAFLD improvement and T2DM incidence. Between 2000...
Gespeichert in:
| Veröffentlicht in: | Diabetes care 2015-09, Vol.38 (9), p.1673-1679 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1679 |
|---|---|
| container_issue | 9 |
| container_start_page | 1673 |
| container_title | Diabetes care |
| container_volume | 38 |
| creator | Yamazaki, Hajime Tsuboya, Toru Tsuji, Kunihiko Dohke, Mitsuru Maguchi, Hiroyuki |
| description | Only a few studies have evaluated the long-term effects of nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and none have examined whether NAFLD improvement reduces T2DM incidence. We investigated the association between NAFLD improvement and T2DM incidence.
Between 2000 and 2012, 4,604 participants who underwent a health check twice with >10 years between were enrolled. Exclusion criteria were positive hepatitis B surface antigen, positive hepatitis C antibody, ethanol intake >20 g/day, and diabetes. The 3,074 eligible participants were divided into an NAFLD group (n = 728) and a non-NAFLD group (n = 2,346) according to ultrasonography-detected fatty liver. The NAFLD group was categorized into an improved group (n = 110) and a sustained NAFLD group (n = 618) based on fatty liver disappearance at the second visit. Incident T2DM odds ratios (ORs) were estimated by logistic regression models adjusted for age, sex, BMI, impaired fasting glucose, family history of diabetes, dyslipidemia, hypertension, and physical exercise.
T2DM occurred in 117 participants (16.1%) in the NAFLD group and 72 (3.1%) in the non-NAFLD group. NAFLD at baseline was associated with T2DM incidence (multivariate OR 2.37 [95% CI 1.60-3.52]). T2DM occurred in 7 participants (6.4%) in the improved group and in 110 (17.8%) in the sustained NAFLD group. NAFLD improvement was associated with reduced T2DM incidence (multivariate OR 0.27 [95% CI 0.12-0.61]).
NAFLD improvement is associated with T2DM incidence reduction. |
| doi_str_mv | 10.2337/dc15-0140 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1706206225</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1706206225</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-7a38f1640be3fc492b73b289577209ffe5a14c98883d8718ab5cf4b42146fe063</originalsourceid><addsrcrecordid>eNpdkU1Lw0AQhhdRbK0e_AOy4EUP0f1MNsf6US0UBannsNnMYkqSrdlE7b93Y6sHYZiBmWdemHkROqXkinGeXBeGyohQQfbQmKZcRlIKtY_GoZVGMk3ZCB15vyKECKHUIRqxmMpYsmSMvuZNAWsIqenw1HtnSt2VrsE30H0CNHher1v3AfUwdxY_uUZXxr25qjR4prtugxflB7T4rvSgPWDdFPgFit5AgeeNKYOwgWFzuVkDZoHTOXTgj9GB1ZWHk12doNfZ_fL2MVo8P8xvp4vICCq6KNFcWRoLkgO3RqQsT3jOVCqThJHUWpCaCpMqpXihEqp0Lo0VuWBUxBZIzCfoYqsbznjvwXdZXXoDVaUbcL3PaEJiFoLJgJ7_Q1eub8O9P5QK75OUBOpyS5nWed-CzdZtWet2k1GSDXZkgx3ZYEdgz3aKfV5D8Uf-_p9_A3IfhBQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1708000510</pqid></control><display><type>article</type><title>Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Yamazaki, Hajime ; Tsuboya, Toru ; Tsuji, Kunihiko ; Dohke, Mitsuru ; Maguchi, Hiroyuki</creator><creatorcontrib>Yamazaki, Hajime ; Tsuboya, Toru ; Tsuji, Kunihiko ; Dohke, Mitsuru ; Maguchi, Hiroyuki</creatorcontrib><description>Only a few studies have evaluated the long-term effects of nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and none have examined whether NAFLD improvement reduces T2DM incidence. We investigated the association between NAFLD improvement and T2DM incidence.
Between 2000 and 2012, 4,604 participants who underwent a health check twice with >10 years between were enrolled. Exclusion criteria were positive hepatitis B surface antigen, positive hepatitis C antibody, ethanol intake >20 g/day, and diabetes. The 3,074 eligible participants were divided into an NAFLD group (n = 728) and a non-NAFLD group (n = 2,346) according to ultrasonography-detected fatty liver. The NAFLD group was categorized into an improved group (n = 110) and a sustained NAFLD group (n = 618) based on fatty liver disappearance at the second visit. Incident T2DM odds ratios (ORs) were estimated by logistic regression models adjusted for age, sex, BMI, impaired fasting glucose, family history of diabetes, dyslipidemia, hypertension, and physical exercise.
T2DM occurred in 117 participants (16.1%) in the NAFLD group and 72 (3.1%) in the non-NAFLD group. NAFLD at baseline was associated with T2DM incidence (multivariate OR 2.37 [95% CI 1.60-3.52]). T2DM occurred in 7 participants (6.4%) in the improved group and in 110 (17.8%) in the sustained NAFLD group. NAFLD improvement was associated with reduced T2DM incidence (multivariate OR 0.27 [95% CI 0.12-0.61]).
NAFLD improvement is associated with T2DM incidence reduction.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc15-0140</identifier><identifier>PMID: 26156527</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Adult ; Aged ; Antigens ; Comorbidity ; Diabetes ; Diabetes Mellitus, Type 2 - epidemiology ; Dyslipidemias - epidemiology ; Female ; Glucose ; Hepatitis ; Humans ; Incidence ; Liver diseases ; Logistic Models ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - epidemiology ; Non-alcoholic Fatty Liver Disease - prevention & control ; Odds Ratio ; Prediabetic State - epidemiology ; Regression analysis ; Risk Factors</subject><ispartof>Diabetes care, 2015-09, Vol.38 (9), p.1673-1679</ispartof><rights>2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.</rights><rights>Copyright American Diabetes Association Sep 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-7a38f1640be3fc492b73b289577209ffe5a14c98883d8718ab5cf4b42146fe063</citedby><cites>FETCH-LOGICAL-c414t-7a38f1640be3fc492b73b289577209ffe5a14c98883d8718ab5cf4b42146fe063</cites><orcidid>0000-0002-9034-4370</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26156527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamazaki, Hajime</creatorcontrib><creatorcontrib>Tsuboya, Toru</creatorcontrib><creatorcontrib>Tsuji, Kunihiko</creatorcontrib><creatorcontrib>Dohke, Mitsuru</creatorcontrib><creatorcontrib>Maguchi, Hiroyuki</creatorcontrib><title>Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Only a few studies have evaluated the long-term effects of nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and none have examined whether NAFLD improvement reduces T2DM incidence. We investigated the association between NAFLD improvement and T2DM incidence.
Between 2000 and 2012, 4,604 participants who underwent a health check twice with >10 years between were enrolled. Exclusion criteria were positive hepatitis B surface antigen, positive hepatitis C antibody, ethanol intake >20 g/day, and diabetes. The 3,074 eligible participants were divided into an NAFLD group (n = 728) and a non-NAFLD group (n = 2,346) according to ultrasonography-detected fatty liver. The NAFLD group was categorized into an improved group (n = 110) and a sustained NAFLD group (n = 618) based on fatty liver disappearance at the second visit. Incident T2DM odds ratios (ORs) were estimated by logistic regression models adjusted for age, sex, BMI, impaired fasting glucose, family history of diabetes, dyslipidemia, hypertension, and physical exercise.
T2DM occurred in 117 participants (16.1%) in the NAFLD group and 72 (3.1%) in the non-NAFLD group. NAFLD at baseline was associated with T2DM incidence (multivariate OR 2.37 [95% CI 1.60-3.52]). T2DM occurred in 7 participants (6.4%) in the improved group and in 110 (17.8%) in the sustained NAFLD group. NAFLD improvement was associated with reduced T2DM incidence (multivariate OR 0.27 [95% CI 0.12-0.61]).
NAFLD improvement is associated with T2DM incidence reduction.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Comorbidity</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Dyslipidemias - epidemiology</subject><subject>Female</subject><subject>Glucose</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Incidence</subject><subject>Liver diseases</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-alcoholic Fatty Liver Disease - epidemiology</subject><subject>Non-alcoholic Fatty Liver Disease - prevention & control</subject><subject>Odds Ratio</subject><subject>Prediabetic State - epidemiology</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1Lw0AQhhdRbK0e_AOy4EUP0f1MNsf6US0UBannsNnMYkqSrdlE7b93Y6sHYZiBmWdemHkROqXkinGeXBeGyohQQfbQmKZcRlIKtY_GoZVGMk3ZCB15vyKECKHUIRqxmMpYsmSMvuZNAWsIqenw1HtnSt2VrsE30H0CNHher1v3AfUwdxY_uUZXxr25qjR4prtugxflB7T4rvSgPWDdFPgFit5AgeeNKYOwgWFzuVkDZoHTOXTgj9GB1ZWHk12doNfZ_fL2MVo8P8xvp4vICCq6KNFcWRoLkgO3RqQsT3jOVCqThJHUWpCaCpMqpXihEqp0Lo0VuWBUxBZIzCfoYqsbznjvwXdZXXoDVaUbcL3PaEJiFoLJgJ7_Q1eub8O9P5QK75OUBOpyS5nWed-CzdZtWet2k1GSDXZkgx3ZYEdgz3aKfV5D8Uf-_p9_A3IfhBQ</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Yamazaki, Hajime</creator><creator>Tsuboya, Toru</creator><creator>Tsuji, Kunihiko</creator><creator>Dohke, Mitsuru</creator><creator>Maguchi, Hiroyuki</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9034-4370</orcidid></search><sort><creationdate>20150901</creationdate><title>Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes</title><author>Yamazaki, Hajime ; Tsuboya, Toru ; Tsuji, Kunihiko ; Dohke, Mitsuru ; Maguchi, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-7a38f1640be3fc492b73b289577209ffe5a14c98883d8718ab5cf4b42146fe063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Comorbidity</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Dyslipidemias - epidemiology</topic><topic>Female</topic><topic>Glucose</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Incidence</topic><topic>Liver diseases</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-alcoholic Fatty Liver Disease - epidemiology</topic><topic>Non-alcoholic Fatty Liver Disease - prevention & control</topic><topic>Odds Ratio</topic><topic>Prediabetic State - epidemiology</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamazaki, Hajime</creatorcontrib><creatorcontrib>Tsuboya, Toru</creatorcontrib><creatorcontrib>Tsuji, Kunihiko</creatorcontrib><creatorcontrib>Dohke, Mitsuru</creatorcontrib><creatorcontrib>Maguchi, Hiroyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamazaki, Hajime</au><au>Tsuboya, Toru</au><au>Tsuji, Kunihiko</au><au>Dohke, Mitsuru</au><au>Maguchi, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>38</volume><issue>9</issue><spage>1673</spage><epage>1679</epage><pages>1673-1679</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>Only a few studies have evaluated the long-term effects of nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and none have examined whether NAFLD improvement reduces T2DM incidence. We investigated the association between NAFLD improvement and T2DM incidence.
Between 2000 and 2012, 4,604 participants who underwent a health check twice with >10 years between were enrolled. Exclusion criteria were positive hepatitis B surface antigen, positive hepatitis C antibody, ethanol intake >20 g/day, and diabetes. The 3,074 eligible participants were divided into an NAFLD group (n = 728) and a non-NAFLD group (n = 2,346) according to ultrasonography-detected fatty liver. The NAFLD group was categorized into an improved group (n = 110) and a sustained NAFLD group (n = 618) based on fatty liver disappearance at the second visit. Incident T2DM odds ratios (ORs) were estimated by logistic regression models adjusted for age, sex, BMI, impaired fasting glucose, family history of diabetes, dyslipidemia, hypertension, and physical exercise.
T2DM occurred in 117 participants (16.1%) in the NAFLD group and 72 (3.1%) in the non-NAFLD group. NAFLD at baseline was associated with T2DM incidence (multivariate OR 2.37 [95% CI 1.60-3.52]). T2DM occurred in 7 participants (6.4%) in the improved group and in 110 (17.8%) in the sustained NAFLD group. NAFLD improvement was associated with reduced T2DM incidence (multivariate OR 0.27 [95% CI 0.12-0.61]).
NAFLD improvement is associated with T2DM incidence reduction.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>26156527</pmid><doi>10.2337/dc15-0140</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9034-4370</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-5992 |
| ispartof | Diabetes care, 2015-09, Vol.38 (9), p.1673-1679 |
| issn | 0149-5992 1935-5548 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1706206225 |
| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Antigens Comorbidity Diabetes Diabetes Mellitus, Type 2 - epidemiology Dyslipidemias - epidemiology Female Glucose Hepatitis Humans Incidence Liver diseases Logistic Models Male Middle Aged Non-alcoholic Fatty Liver Disease - epidemiology Non-alcoholic Fatty Liver Disease - prevention & control Odds Ratio Prediabetic State - epidemiology Regression analysis Risk Factors |
| title | Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T07%3A12%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Independent%20Association%20Between%20Improvement%20of%20Nonalcoholic%20Fatty%20Liver%20Disease%20and%20Reduced%20Incidence%20of%20Type%202%20Diabetes&rft.jtitle=Diabetes%20care&rft.au=Yamazaki,%20Hajime&rft.date=2015-09-01&rft.volume=38&rft.issue=9&rft.spage=1673&rft.epage=1679&rft.pages=1673-1679&rft.issn=0149-5992&rft.eissn=1935-5548&rft.coden=DICAD2&rft_id=info:doi/10.2337/dc15-0140&rft_dat=%3Cproquest_cross%3E1706206225%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1708000510&rft_id=info:pmid/26156527&rfr_iscdi=true |