Antagonists of N-methyl-D-aspartate receptors partially prevent the development of cocaine sensitization

Antagonists of N-methyl-D-aspartate receptors partially prevent the development of cocaine sensitization

Behavioral sensitization to cocaine was tested for in rats pretreated with MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, or D-3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid (D-CPPene), a competitive NMDA antagonist. A 5-day regimen of once-daily cocaine (15 mg/k...

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Veröffentlicht in:Life sciences (1973) 1995-11, Vol.57 (25), p.2347-2357
Hauptverfasser: Haracz, John L., Belanger, Susan A., MacDonall, James S., Sircar, Ratna
Format: Artikel
Sprache:eng
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cocaine
D-CPPene
dizocilpine
N-methyl-D-aspartale
sensitization
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container_end_page 2357
container_issue 25
container_start_page 2347
container_title Life sciences (1973)
container_volume 57
creator Haracz, John L.
Belanger, Susan A.
MacDonall, James S.
Sircar, Ratna
description Behavioral sensitization to cocaine was tested for in rats pretreated with MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, or D-3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid (D-CPPene), a competitive NMDA antagonist. A 5-day regimen of once-daily cocaine (15 mg/kg) injections yielded sensitization to cocaine (15 mg/kg)-induced behavioral activation. Cocaine sensitization was partially prevented by MK-801 (0.25 mg/kg) or D-CPPene (20 mg/kg) pretreatment. These results differ from previous reports that NMDA receptor antagonists completely prevented the development of stimulant sensitization. While raising questions about methodological differences among laboratories studying this issue, our findings suggest that sensitization may involve mechanisms dependent on NMDA-receptor function as well as NMDA receptorindependent mechanisms.
doi_str_mv 10.1016/0024-3205(95)02229-C
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source Elsevier ScienceDirect Journals
subjects cocaine
D-CPPene
dizocilpine
N-methyl-D-aspartale
sensitization
title Antagonists of N-methyl-D-aspartate receptors partially prevent the development of cocaine sensitization
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