Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery
In this study, pH, reduction and light triple-responsive nanocarriers based on hollow mesoporous silica nanoparticles (HMSNs) modified with poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) were developed via surface-initiated atom transfer radical polymerization. Both reduction-cleavable disulfi...
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| Veröffentlicht in: | ACS applied materials & interfaces 2015-08, Vol.7 (32), p.18179-18187 |
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| creator | Zhang, Yuanyuan Ang, Chung Yen Li, Menghuan Tan, Si Yu Qu, Qiuyu Luo, Zhong Zhao, Yanli |
| description | In this study, pH, reduction and light triple-responsive nanocarriers based on hollow mesoporous silica nanoparticles (HMSNs) modified with poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) were developed via surface-initiated atom transfer radical polymerization. Both reduction-cleavable disulfide bond and light-cleavable o-nitrobenzyl ester were used as the linkages between HMSNs and pH-sensitive PDEAEMA polymer caps. A series of characterization techniques were applied to characterize and confirm the structures of the intermediates and final nanocarriers. Doxorubicin (DOX) was easily encapsulated into the nanocarriers with a high loading capacity, and quickly released in response to the stimuli of reducing agent, acid environment or UV light irradiation. In addition, flow cytometry analysis, confocal laser scanning microscopy observations and cytotoxicity studies indicated that the nanocarriers were efficiently internalized by HeLa cancer cells, exhibiting (i) enhanced release of DOX into the cytoplasm under external UV light irradiation, (ii) better cytotoxicity against HeLa cells, and (iii) superior control over drug delivery and release. Thus, the triple-responsive nanocarriers present highly promising potentials as a drug delivery platform for cancer therapy. |
| doi_str_mv | 10.1021/acsami.5b05893 |
| format | Article |
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Both reduction-cleavable disulfide bond and light-cleavable o-nitrobenzyl ester were used as the linkages between HMSNs and pH-sensitive PDEAEMA polymer caps. A series of characterization techniques were applied to characterize and confirm the structures of the intermediates and final nanocarriers. Doxorubicin (DOX) was easily encapsulated into the nanocarriers with a high loading capacity, and quickly released in response to the stimuli of reducing agent, acid environment or UV light irradiation. In addition, flow cytometry analysis, confocal laser scanning microscopy observations and cytotoxicity studies indicated that the nanocarriers were efficiently internalized by HeLa cancer cells, exhibiting (i) enhanced release of DOX into the cytoplasm under external UV light irradiation, (ii) better cytotoxicity against HeLa cells, and (iii) superior control over drug delivery and release. Thus, the triple-responsive nanocarriers present highly promising potentials as a drug delivery platform for cancer therapy.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.5b05893</identifier><identifier>PMID: 26221866</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Antibiotics, Antineoplastic - chemistry ; Antibiotics, Antineoplastic - toxicity ; Cell Survival - drug effects ; Disulfides - chemistry ; Doxorubicin - chemistry ; Doxorubicin - toxicity ; Drug Carriers - chemical synthesis ; Drug Carriers - chemistry ; Drug Liberation - radiation effects ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Methacrylates - chemistry ; Microscopy, Confocal ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Nylons - chemistry ; Photoelectron Spectroscopy ; Porosity ; Silicon Dioxide - chemistry ; Spectroscopy, Fourier Transform Infrared ; Ultraviolet Rays</subject><ispartof>ACS applied materials & interfaces, 2015-08, Vol.7 (32), p.18179-18187</ispartof><rights>Copyright © American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a396t-4cfef63a14f169ee3938e6a7a85ecbe1ade0cea8c0d54e03325c9b7b29c988073</citedby><cites>FETCH-LOGICAL-a396t-4cfef63a14f169ee3938e6a7a85ecbe1ade0cea8c0d54e03325c9b7b29c988073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.5b05893$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.5b05893$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,777,781,2752,27057,27905,27906,56719,56769</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26221866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yuanyuan</creatorcontrib><creatorcontrib>Ang, Chung Yen</creatorcontrib><creatorcontrib>Li, Menghuan</creatorcontrib><creatorcontrib>Tan, Si Yu</creatorcontrib><creatorcontrib>Qu, Qiuyu</creatorcontrib><creatorcontrib>Luo, Zhong</creatorcontrib><creatorcontrib>Zhao, Yanli</creatorcontrib><title>Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. Mater. Interfaces</addtitle><description>In this study, pH, reduction and light triple-responsive nanocarriers based on hollow mesoporous silica nanoparticles (HMSNs) modified with poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) were developed via surface-initiated atom transfer radical polymerization. Both reduction-cleavable disulfide bond and light-cleavable o-nitrobenzyl ester were used as the linkages between HMSNs and pH-sensitive PDEAEMA polymer caps. A series of characterization techniques were applied to characterize and confirm the structures of the intermediates and final nanocarriers. Doxorubicin (DOX) was easily encapsulated into the nanocarriers with a high loading capacity, and quickly released in response to the stimuli of reducing agent, acid environment or UV light irradiation. In addition, flow cytometry analysis, confocal laser scanning microscopy observations and cytotoxicity studies indicated that the nanocarriers were efficiently internalized by HeLa cancer cells, exhibiting (i) enhanced release of DOX into the cytoplasm under external UV light irradiation, (ii) better cytotoxicity against HeLa cells, and (iii) superior control over drug delivery and release. Thus, the triple-responsive nanocarriers present highly promising potentials as a drug delivery platform for cancer therapy.</description><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics, Antineoplastic - toxicity</subject><subject>Cell Survival - drug effects</subject><subject>Disulfides - chemistry</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - toxicity</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Liberation - radiation effects</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Methacrylates - chemistry</subject><subject>Microscopy, Confocal</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Nylons - chemistry</subject><subject>Photoelectron Spectroscopy</subject><subject>Porosity</subject><subject>Silicon Dioxide - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Ultraviolet Rays</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EouWxMqKMCCnF7yQjaoEilYegDEyR49wgV04d7ATUf09QSjeme4fzfbr3IHRG8IRgSq6UDqo2E1FgkWZsD41JxnmcUkH3dzvnI3QUwgpjySgWh2hEJaUklXKM3p-d3dTg46lTLZTR3FnrvqMHCK5x3nUhejXWaBU9qrVrlG-NthCiyvlo6U1jIX6B0Lh1MF8QzXz3Ec3A9rvfnKCDStkAp9t5jN5ub5bTebx4urufXi9ixTLZxlxXUEmmCK-IzABYxlKQKlGpAF0AUSVgDSrVuBQcMGNU6KxICprpLE1xwo7RxdDbePfZQWjz2gQN1qo19PfnJMEiYYIlvEcnA6q9C8FDlTfe1MpvcoLzX535oDPf6uwD59vurqih3OF__nrgcgD6YL5ynV_3r_7X9gMVhYFF</recordid><startdate>20150819</startdate><enddate>20150819</enddate><creator>Zhang, Yuanyuan</creator><creator>Ang, Chung Yen</creator><creator>Li, Menghuan</creator><creator>Tan, Si Yu</creator><creator>Qu, Qiuyu</creator><creator>Luo, Zhong</creator><creator>Zhao, Yanli</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150819</creationdate><title>Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery</title><author>Zhang, Yuanyuan ; Ang, Chung Yen ; Li, Menghuan ; Tan, Si Yu ; Qu, Qiuyu ; Luo, Zhong ; Zhao, Yanli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a396t-4cfef63a14f169ee3938e6a7a85ecbe1ade0cea8c0d54e03325c9b7b29c988073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Antibiotics, Antineoplastic - toxicity</topic><topic>Cell Survival - drug effects</topic><topic>Disulfides - chemistry</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - toxicity</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Liberation - radiation effects</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Methacrylates - chemistry</topic><topic>Microscopy, Confocal</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Nylons - chemistry</topic><topic>Photoelectron Spectroscopy</topic><topic>Porosity</topic><topic>Silicon Dioxide - chemistry</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yuanyuan</creatorcontrib><creatorcontrib>Ang, Chung Yen</creatorcontrib><creatorcontrib>Li, Menghuan</creatorcontrib><creatorcontrib>Tan, Si Yu</creatorcontrib><creatorcontrib>Qu, Qiuyu</creatorcontrib><creatorcontrib>Luo, Zhong</creatorcontrib><creatorcontrib>Zhao, Yanli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yuanyuan</au><au>Ang, Chung Yen</au><au>Li, Menghuan</au><au>Tan, Si Yu</au><au>Qu, Qiuyu</au><au>Luo, Zhong</au><au>Zhao, Yanli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2015-08-19</date><risdate>2015</risdate><volume>7</volume><issue>32</issue><spage>18179</spage><epage>18187</epage><pages>18179-18187</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>In this study, pH, reduction and light triple-responsive nanocarriers based on hollow mesoporous silica nanoparticles (HMSNs) modified with poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) were developed via surface-initiated atom transfer radical polymerization. Both reduction-cleavable disulfide bond and light-cleavable o-nitrobenzyl ester were used as the linkages between HMSNs and pH-sensitive PDEAEMA polymer caps. A series of characterization techniques were applied to characterize and confirm the structures of the intermediates and final nanocarriers. Doxorubicin (DOX) was easily encapsulated into the nanocarriers with a high loading capacity, and quickly released in response to the stimuli of reducing agent, acid environment or UV light irradiation. In addition, flow cytometry analysis, confocal laser scanning microscopy observations and cytotoxicity studies indicated that the nanocarriers were efficiently internalized by HeLa cancer cells, exhibiting (i) enhanced release of DOX into the cytoplasm under external UV light irradiation, (ii) better cytotoxicity against HeLa cells, and (iii) superior control over drug delivery and release. Thus, the triple-responsive nanocarriers present highly promising potentials as a drug delivery platform for cancer therapy.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>26221866</pmid><doi>10.1021/acsami.5b05893</doi><tpages>9</tpages></addata></record> |
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| subjects | Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - toxicity Cell Survival - drug effects Disulfides - chemistry Doxorubicin - chemistry Doxorubicin - toxicity Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Liberation - radiation effects HeLa Cells Humans Hydrogen-Ion Concentration Methacrylates - chemistry Microscopy, Confocal Nanoparticles - chemistry Nanoparticles - ultrastructure Nylons - chemistry Photoelectron Spectroscopy Porosity Silicon Dioxide - chemistry Spectroscopy, Fourier Transform Infrared Ultraviolet Rays |
| title | Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery |
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