Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug–Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release

Integrating advantages of mitomycin C (MMC)–phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC–phospholipid complex-loaded...

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Veröffentlicht in:	ACS applied materials & interfaces 2015-08, Vol.7 (32), p.17573-17581
Hauptverfasser:	Li, Yang, Lin, Jinyan, Yang, Xiangrui, Li, Yanxiu, Wu, Shichao, Huang, Yu, Ye, Shefang, Xie, Liya, Dai, Lizong, Hou, Zhenqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Cell Survival - drug effects Drug Carriers - chemistry Drug Carriers - metabolism Drug Carriers - toxicity Drug Liberation Female Folic Acid - analogs & derivatives Folic Acid - chemistry Half-Life HeLa Cells Humans Mice Mice, Nude Microscopy, Confocal Mitomycin - administration & dosage Mitomycin - chemistry Mitomycin - pharmacokinetics Nanoparticles - chemistry Phospholipids - chemistry Polyethylene Glycols - chemistry Rats Tissue Distribution Transplantation, Heterologous Uterine Cervical Neoplasms - drug therapy
Online-Zugang:	Volltext
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