Didanosine (ddl) and stavudine (d4T): Absence of peripheral neurotoxicity in rabbits
Some 20 male New Zealand White rabbits (five/group) were given either didanosine (ddl) or stavudine (d4T) at 750 and 1500 mg/kg body weight/day by oral intubation for 24 wk. An additional group was given 300 mg/kg body weight/day zidovudine (AZT) as a negative control. After 13 weeks the high dose o...
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| Veröffentlicht in: | Food and chemical toxicology 1995-12, Vol.33 (12), p.1047-1050 |
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| creator | Warner, W.A. Bregman, C.L. Comereski, C.R Arezzo, J.C. Davidson, T.J. Knupp, C.A. Kaul, S. Durham, S.K. Wasserman, A.J. Frantz, J.D. |
| description | Some 20 male New Zealand White rabbits (five/group) were given either didanosine (ddl) or stavudine (d4T) at 750 and 1500 mg/kg body weight/day by oral intubation for 24 wk. An additional group was given 300 mg/kg body weight/day zidovudine (AZT) as a negative control. After 13 weeks the high dose of ddl was lowered from 1500 to 1000 mg/kg body weight/day following the death of one rabbit and continued inappetence in the dose group. The rabbits were observed daily, plasma drug levels were monitored, and electrophysiological measurements of peripheral nerve conduction were performed during the study. Additionally, body weight and food intake were recorded, and clinicopathological parameters were evaluated. Sections of selected peripheral nerves, and dorsal and ventral spinal nerve roots were examined by light and transmission electron microscopy. Although peripheral neuropathy has been reported in rabbits with the nucleoside analogue zalcitabine (ddC), based on clinical observations, electrophysiological measurements, and light and electron microscopy, no evidence of peripheral neurotoxicity was observed in rabbits given either ddl or d4T. |
| doi_str_mv | 10.1016/0278-6915(95)00078-X |
| format | Article |
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An additional group was given 300 mg/kg body weight/day zidovudine (AZT) as a negative control. After 13 weeks the high dose of ddl was lowered from 1500 to 1000 mg/kg body weight/day following the death of one rabbit and continued inappetence in the dose group. The rabbits were observed daily, plasma drug levels were monitored, and electrophysiological measurements of peripheral nerve conduction were performed during the study. Additionally, body weight and food intake were recorded, and clinicopathological parameters were evaluated. Sections of selected peripheral nerves, and dorsal and ventral spinal nerve roots were examined by light and transmission electron microscopy. Although peripheral neuropathy has been reported in rabbits with the nucleoside analogue zalcitabine (ddC), based on clinical observations, electrophysiological measurements, and light and electron microscopy, no evidence of peripheral neurotoxicity was observed in rabbits given either ddl or d4T.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/0278-6915(95)00078-X</identifier><identifier>PMID: 8847000</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antiviral Agents - toxicity ; Biological and medical sciences ; Didanosine - blood ; Didanosine - toxicity ; Drug toxicity and drugs side effects treatment ; Male ; Medical sciences ; Microscopy, Electron ; nervous system ; Neural Conduction - drug effects ; Neurons - drug effects ; nucleosides ; Peripheral Nerves - drug effects ; Peripheral Nerves - pathology ; Pharmacology. Drug treatments ; Rabbits ; Sciatic Nerve - drug effects ; Sciatic Nerve - pathology ; Sciatic Nerve - ultrastructure ; Spinal Nerves - drug effects ; Spinal Nerves - pathology ; Spinal Nerves - ultrastructure ; Stavudine - blood ; Stavudine - toxicity ; toxicity ; Toxicity: nervous system and muscle ; Zidovudine - blood</subject><ispartof>Food and chemical toxicology, 1995-12, Vol.33 (12), p.1047-1050</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-429f73fa661fd822f519708d7a19cac4091ab0e116d90fcf638db7e93541fbe63</citedby><cites>FETCH-LOGICAL-c441t-429f73fa661fd822f519708d7a19cac4091ab0e116d90fcf638db7e93541fbe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/027869159500078X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2949958$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8847000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warner, W.A.</creatorcontrib><creatorcontrib>Bregman, C.L.</creatorcontrib><creatorcontrib>Comereski, C.R</creatorcontrib><creatorcontrib>Arezzo, J.C.</creatorcontrib><creatorcontrib>Davidson, T.J.</creatorcontrib><creatorcontrib>Knupp, C.A.</creatorcontrib><creatorcontrib>Kaul, S.</creatorcontrib><creatorcontrib>Durham, S.K.</creatorcontrib><creatorcontrib>Wasserman, A.J.</creatorcontrib><creatorcontrib>Frantz, J.D.</creatorcontrib><title>Didanosine (ddl) and stavudine (d4T): Absence of peripheral neurotoxicity in rabbits</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Some 20 male New Zealand White rabbits (five/group) were given either didanosine (ddl) or stavudine (d4T) at 750 and 1500 mg/kg body weight/day by oral intubation for 24 wk. An additional group was given 300 mg/kg body weight/day zidovudine (AZT) as a negative control. After 13 weeks the high dose of ddl was lowered from 1500 to 1000 mg/kg body weight/day following the death of one rabbit and continued inappetence in the dose group. The rabbits were observed daily, plasma drug levels were monitored, and electrophysiological measurements of peripheral nerve conduction were performed during the study. Additionally, body weight and food intake were recorded, and clinicopathological parameters were evaluated. Sections of selected peripheral nerves, and dorsal and ventral spinal nerve roots were examined by light and transmission electron microscopy. Although peripheral neuropathy has been reported in rabbits with the nucleoside analogue zalcitabine (ddC), based on clinical observations, electrophysiological measurements, and light and electron microscopy, no evidence of peripheral neurotoxicity was observed in rabbits given either ddl or d4T.</description><subject>Animals</subject><subject>Antiviral Agents - toxicity</subject><subject>Biological and medical sciences</subject><subject>Didanosine - blood</subject><subject>Didanosine - toxicity</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>nervous system</subject><subject>Neural Conduction - drug effects</subject><subject>Neurons - drug effects</subject><subject>nucleosides</subject><subject>Peripheral Nerves - drug effects</subject><subject>Peripheral Nerves - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Sciatic Nerve - drug effects</subject><subject>Sciatic Nerve - pathology</subject><subject>Sciatic Nerve - ultrastructure</subject><subject>Spinal Nerves - drug effects</subject><subject>Spinal Nerves - pathology</subject><subject>Spinal Nerves - ultrastructure</subject><subject>Stavudine - blood</subject><subject>Stavudine - toxicity</subject><subject>toxicity</subject><subject>Toxicity: nervous system and muscle</subject><subject>Zidovudine - blood</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxRzENk5tKa68-lBWNZPWPDgLOwtpPOhkZ7OmHQv7r83bQ9z9FRUvU8VxYPQcyBvgAB_S1ohG66AXSi2JYTU7vYB2oAUXcM7Bg_R5oQ8Rk9K-bVAIPgZOpOSitpt0O5DdGZMJY4eXzg3bLEZHS6TuZvdOqO77Tt82Rc_Wo9TwAef4-Gnz2bAo59zmtKfaON0j-OIs-n7OJWn6FEwQ_HPjvUc3Xz6uLv60lx_-_z16vK6sZTC1NBWBdEFwzkEJ9s2MFCCSCcMKGssJQpMTzwAd4oEG3gnXS-86hiF0HvenaPX691DTr9nXya9j8X6YTCjT3PRIAjjvO0qSFfQ5lRK9kEfctybfK-B6EWmXkzpxZRWTP-TqW_r2ovj_bnfe3daOtqr-atjboo1Q8hmtLGcsFZRpZis2MsVCyZp8yNX5OZ7S6AjwABkRyvxfiV8tXUXfdbFxkW4i9nbSbsU___pX7sNmIw</recordid><startdate>19951201</startdate><enddate>19951201</enddate><creator>Warner, W.A.</creator><creator>Bregman, C.L.</creator><creator>Comereski, C.R</creator><creator>Arezzo, J.C.</creator><creator>Davidson, T.J.</creator><creator>Knupp, C.A.</creator><creator>Kaul, S.</creator><creator>Durham, S.K.</creator><creator>Wasserman, A.J.</creator><creator>Frantz, J.D.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19951201</creationdate><title>Didanosine (ddl) and stavudine (d4T): Absence of peripheral neurotoxicity in rabbits</title><author>Warner, W.A. ; Bregman, C.L. ; Comereski, C.R ; Arezzo, J.C. ; Davidson, T.J. ; Knupp, C.A. ; Kaul, S. ; Durham, S.K. ; Wasserman, A.J. ; Frantz, J.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-429f73fa661fd822f519708d7a19cac4091ab0e116d90fcf638db7e93541fbe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antiviral Agents - toxicity</topic><topic>Biological and medical sciences</topic><topic>Didanosine - blood</topic><topic>Didanosine - toxicity</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>nervous system</topic><topic>Neural Conduction - drug effects</topic><topic>Neurons - drug effects</topic><topic>nucleosides</topic><topic>Peripheral Nerves - drug effects</topic><topic>Peripheral Nerves - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Sciatic Nerve - drug effects</topic><topic>Sciatic Nerve - pathology</topic><topic>Sciatic Nerve - ultrastructure</topic><topic>Spinal Nerves - drug effects</topic><topic>Spinal Nerves - pathology</topic><topic>Spinal Nerves - ultrastructure</topic><topic>Stavudine - blood</topic><topic>Stavudine - toxicity</topic><topic>toxicity</topic><topic>Toxicity: nervous system and muscle</topic><topic>Zidovudine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warner, W.A.</creatorcontrib><creatorcontrib>Bregman, C.L.</creatorcontrib><creatorcontrib>Comereski, C.R</creatorcontrib><creatorcontrib>Arezzo, J.C.</creatorcontrib><creatorcontrib>Davidson, T.J.</creatorcontrib><creatorcontrib>Knupp, C.A.</creatorcontrib><creatorcontrib>Kaul, S.</creatorcontrib><creatorcontrib>Durham, S.K.</creatorcontrib><creatorcontrib>Wasserman, A.J.</creatorcontrib><creatorcontrib>Frantz, J.D.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warner, W.A.</au><au>Bregman, C.L.</au><au>Comereski, C.R</au><au>Arezzo, J.C.</au><au>Davidson, T.J.</au><au>Knupp, C.A.</au><au>Kaul, S.</au><au>Durham, S.K.</au><au>Wasserman, A.J.</au><au>Frantz, J.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Didanosine (ddl) and stavudine (d4T): Absence of peripheral neurotoxicity in rabbits</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>1995-12-01</date><risdate>1995</risdate><volume>33</volume><issue>12</issue><spage>1047</spage><epage>1050</epage><pages>1047-1050</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Some 20 male New Zealand White rabbits (five/group) were given either didanosine (ddl) or stavudine (d4T) at 750 and 1500 mg/kg body weight/day by oral intubation for 24 wk. An additional group was given 300 mg/kg body weight/day zidovudine (AZT) as a negative control. After 13 weeks the high dose of ddl was lowered from 1500 to 1000 mg/kg body weight/day following the death of one rabbit and continued inappetence in the dose group. The rabbits were observed daily, plasma drug levels were monitored, and electrophysiological measurements of peripheral nerve conduction were performed during the study. Additionally, body weight and food intake were recorded, and clinicopathological parameters were evaluated. Sections of selected peripheral nerves, and dorsal and ventral spinal nerve roots were examined by light and transmission electron microscopy. Although peripheral neuropathy has been reported in rabbits with the nucleoside analogue zalcitabine (ddC), based on clinical observations, electrophysiological measurements, and light and electron microscopy, no evidence of peripheral neurotoxicity was observed in rabbits given either ddl or d4T.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>8847000</pmid><doi>10.1016/0278-6915(95)00078-X</doi><tpages>4</tpages></addata></record> |
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| ispartof | Food and chemical toxicology, 1995-12, Vol.33 (12), p.1047-1050 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antiviral Agents - toxicity Biological and medical sciences Didanosine - blood Didanosine - toxicity Drug toxicity and drugs side effects treatment Male Medical sciences Microscopy, Electron nervous system Neural Conduction - drug effects Neurons - drug effects nucleosides Peripheral Nerves - drug effects Peripheral Nerves - pathology Pharmacology. Drug treatments Rabbits Sciatic Nerve - drug effects Sciatic Nerve - pathology Sciatic Nerve - ultrastructure Spinal Nerves - drug effects Spinal Nerves - pathology Spinal Nerves - ultrastructure Stavudine - blood Stavudine - toxicity toxicity Toxicity: nervous system and muscle Zidovudine - blood |
| title | Didanosine (ddl) and stavudine (d4T): Absence of peripheral neurotoxicity in rabbits |
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