Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides

In this study, three steroidal sapogenins (Δ 3 diosgenin, diosgenin, and pennogenin) and the phytosterols, stigmasterol and β-sitosterol were isolated from Jamaican bitter yam, Dioscorea polygonoides. Their effects on fasting blood glucose and intestinal amylase and ATPases in streptozotocin-induced...

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Veröffentlicht in:	Food and chemical toxicology 2005-11, Vol.43 (11), p.1667-1672
Hauptverfasser:	McAnuff, Marie A., Harding, Wayne W., Omoruyi, Felix O., Jacobs, Helen, Morrison, Errol Y., Asemota, Helen N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism adenosinetriphosphatase alpha-amylase Amylases - metabolism animal models Animals Biological and medical sciences blood glucose Blood Glucose - metabolism Body Weight - drug effects Calcium-Transporting ATPases - metabolism diabetes mellitus Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - metabolism Dioscorea Dioscorea - chemistry Dioscorea - toxicity Dioscorea polygonoides Eating - drug effects enzyme activity glucose tolerance glycemic effect Hypoglycemia Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Intestinal ATPases Intestines - drug effects Intestines - enzymology Medical sciences metabolic syndrome nutrient intake phytosterols plant extracts Rats Sapogenin sapogenins Sapogenins - isolation & purification Sapogenins - pharmacology Sodium-Potassium-Exchanging ATPase - metabolism steroid saponins Steroids - isolation & purification Steroids - pharmacology Toxicology weight loss
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