Ibogaine-like effects of noribogaine in rats
Ibogaine is a naturally occurring alkaloid that has been claimed to be effective in treating addiction to opioids and stimulants; a single dose is claimed to be effective for 6 months. Analogously, studies in rats have demonstrated prolonged (one or more days) effects of ibogaine on morphine and coc...
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| Veröffentlicht in: | Brain research 1996-03, Vol.713 (1), p.294-297 |
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| creator | Glick, S.D. Pearl, S.M. Cai, J. Maisonneuve, I.M. |
| description | Ibogaine is a naturally occurring alkaloid that has been claimed to be effective in treating addiction to opioids and stimulants; a single dose is claimed to be effective for 6 months. Analogously, studies in rats have demonstrated prolonged (one or more days) effects of ibogaine on morphine and cocaine self-administration even though ibogaine is mostly eliminated from the body in several hours. These observations have suggested that a metabolite may mediate some of the effects of ibogaine. Recently, noribogaine was identified as a metabolite of ibogaine. Accordingly, the present study sought to determine, in rats, whether noribogaine had pharmacological effects mimicking those of ibogaine. Noribogaine (40 mg/kg[ was found to decrease morphine and cocaine self-administration, reduce the locomotor stimulant effect of morphine, and decrease extracellular levels of dopamine in the nucleus accumbens and striatum. All of these effects were similar to effects previously observed with ibogaine (40 mg/kg[; however, noribogaine did not induce any ibogaine-like tremors. The results suggest that noribogaine may be a mediator of ibogaine's putative anti-addictive effects. |
| doi_str_mv | 10.1016/0006-8993(95)01563-9 |
| format | Article |
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Analogously, studies in rats have demonstrated prolonged (one or more days) effects of ibogaine on morphine and cocaine self-administration even though ibogaine is mostly eliminated from the body in several hours. These observations have suggested that a metabolite may mediate some of the effects of ibogaine. Recently, noribogaine was identified as a metabolite of ibogaine. Accordingly, the present study sought to determine, in rats, whether noribogaine had pharmacological effects mimicking those of ibogaine. Noribogaine (40 mg/kg[ was found to decrease morphine and cocaine self-administration, reduce the locomotor stimulant effect of morphine, and decrease extracellular levels of dopamine in the nucleus accumbens and striatum. All of these effects were similar to effects previously observed with ibogaine (40 mg/kg[; however, noribogaine did not induce any ibogaine-like tremors. The results suggest that noribogaine may be a mediator of ibogaine's putative anti-addictive effects.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(95)01563-9</identifier><identifier>PMID: 8725004</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cocaine ; Dopamine ; Drug addictions ; Drug self-administration ; Female ; Ibogaine ; Ibogaine - analogs & derivatives ; Ibogaine - pharmacology ; Locomotion - drug effects ; Medical sciences ; Medicine, African Traditional ; Microdialysis ; Morphine ; Morphine - pharmacology ; Noribogaine ; Rats ; Rats, Sprague-Dawley ; Self Administration ; Substance-Related Disorders - therapy ; Time Factors ; Toxicology</subject><ispartof>Brain research, 1996-03, Vol.713 (1), p.294-297</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-86f2b24851894c137858091bf8a2b1efad06b82b0e37b31e2042814b7d179a843</citedby><cites>FETCH-LOGICAL-c417t-86f2b24851894c137858091bf8a2b1efad06b82b0e37b31e2042814b7d179a843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899395015639$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3185605$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8725004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Glick, S.D.</creatorcontrib><creatorcontrib>Pearl, S.M.</creatorcontrib><creatorcontrib>Cai, J.</creatorcontrib><creatorcontrib>Maisonneuve, I.M.</creatorcontrib><title>Ibogaine-like effects of noribogaine in rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Ibogaine is a naturally occurring alkaloid that has been claimed to be effective in treating addiction to opioids and stimulants; a single dose is claimed to be effective for 6 months. Analogously, studies in rats have demonstrated prolonged (one or more days) effects of ibogaine on morphine and cocaine self-administration even though ibogaine is mostly eliminated from the body in several hours. These observations have suggested that a metabolite may mediate some of the effects of ibogaine. Recently, noribogaine was identified as a metabolite of ibogaine. Accordingly, the present study sought to determine, in rats, whether noribogaine had pharmacological effects mimicking those of ibogaine. Noribogaine (40 mg/kg[ was found to decrease morphine and cocaine self-administration, reduce the locomotor stimulant effect of morphine, and decrease extracellular levels of dopamine in the nucleus accumbens and striatum. All of these effects were similar to effects previously observed with ibogaine (40 mg/kg[; however, noribogaine did not induce any ibogaine-like tremors. The results suggest that noribogaine may be a mediator of ibogaine's putative anti-addictive effects.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cocaine</subject><subject>Dopamine</subject><subject>Drug addictions</subject><subject>Drug self-administration</subject><subject>Female</subject><subject>Ibogaine</subject><subject>Ibogaine - analogs & derivatives</subject><subject>Ibogaine - pharmacology</subject><subject>Locomotion - drug effects</subject><subject>Medical sciences</subject><subject>Medicine, African Traditional</subject><subject>Microdialysis</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Noribogaine</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Self Administration</subject><subject>Substance-Related Disorders - therapy</subject><subject>Time Factors</subject><subject>Toxicology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhkVJcRynb9DAHkJJINvOrKRd6VIIpk0Chl7Ss5C0o6JkvetIdqBvn3W8-JjTMPzfDDMfY18RviNg_QMA6lJpza-0vAaUNS_1JzZH1VRlXQk4YfMjcsrOcn4aW841zNhsZCSAmLObBzf8s7GnsovPVFAI5Le5GELRDylOWRH7ItltPmefg-0yfZnqgv39_etxeV-u_tw9LG9XpRfYbEtVh8pVQklUWnjkjZIKNLqgbOWQgm2hdqpyQLxxHKkCUSkUrmmx0VYJvmDfDns3aXjZUd6adcyeus72NOyywQakxPGXBRMH0Kch50TBbFJc2_TfIJi9JLM3YPYGjJbmXZLR49jFtH_n1tQehyYrY3455TZ724Vkex_zEeOoZA1yxH4eMBpdvEZKJvtIvac2ptGiaYf48R1vxxx_5A</recordid><startdate>19960325</startdate><enddate>19960325</enddate><creator>Glick, S.D.</creator><creator>Pearl, S.M.</creator><creator>Cai, J.</creator><creator>Maisonneuve, I.M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19960325</creationdate><title>Ibogaine-like effects of noribogaine in rats</title><author>Glick, S.D. ; Pearl, S.M. ; Cai, J. ; Maisonneuve, I.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-86f2b24851894c137858091bf8a2b1efad06b82b0e37b31e2042814b7d179a843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cocaine</topic><topic>Dopamine</topic><topic>Drug addictions</topic><topic>Drug self-administration</topic><topic>Female</topic><topic>Ibogaine</topic><topic>Ibogaine - analogs & derivatives</topic><topic>Ibogaine - pharmacology</topic><topic>Locomotion - drug effects</topic><topic>Medical sciences</topic><topic>Medicine, African Traditional</topic><topic>Microdialysis</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Noribogaine</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Self Administration</topic><topic>Substance-Related Disorders - therapy</topic><topic>Time Factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Glick, S.D.</creatorcontrib><creatorcontrib>Pearl, S.M.</creatorcontrib><creatorcontrib>Cai, J.</creatorcontrib><creatorcontrib>Maisonneuve, I.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Glick, S.D.</au><au>Pearl, S.M.</au><au>Cai, J.</au><au>Maisonneuve, I.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ibogaine-like effects of noribogaine in rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1996-03-25</date><risdate>1996</risdate><volume>713</volume><issue>1</issue><spage>294</spage><epage>297</epage><pages>294-297</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Ibogaine is a naturally occurring alkaloid that has been claimed to be effective in treating addiction to opioids and stimulants; a single dose is claimed to be effective for 6 months. Analogously, studies in rats have demonstrated prolonged (one or more days) effects of ibogaine on morphine and cocaine self-administration even though ibogaine is mostly eliminated from the body in several hours. These observations have suggested that a metabolite may mediate some of the effects of ibogaine. Recently, noribogaine was identified as a metabolite of ibogaine. Accordingly, the present study sought to determine, in rats, whether noribogaine had pharmacological effects mimicking those of ibogaine. Noribogaine (40 mg/kg[ was found to decrease morphine and cocaine self-administration, reduce the locomotor stimulant effect of morphine, and decrease extracellular levels of dopamine in the nucleus accumbens and striatum. All of these effects were similar to effects previously observed with ibogaine (40 mg/kg[; however, noribogaine did not induce any ibogaine-like tremors. 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| ispartof | Brain research, 1996-03, Vol.713 (1), p.294-297 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cocaine Dopamine Drug addictions Drug self-administration Female Ibogaine Ibogaine - analogs & derivatives Ibogaine - pharmacology Locomotion - drug effects Medical sciences Medicine, African Traditional Microdialysis Morphine Morphine - pharmacology Noribogaine Rats Rats, Sprague-Dawley Self Administration Substance-Related Disorders - therapy Time Factors Toxicology |
| title | Ibogaine-like effects of noribogaine in rats |
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