Mechanisms underlying the vasorelaxation of human internal mammary artery induced by (-)-epicatechin

Evidences have suggested that flavanol compound (-)-epicatechin is associated with reduced risk of cardiovascular diseases. One of the mechanisms of its cardioprotective effect is vasodilation. However, the exact mechanisms by which (-)-epicatechin causes vasodilation are not yet clearly defined. Th...

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Veröffentlicht in:	European journal of pharmacology 2015-09, Vol.762, p.306-312
Hauptverfasser:	Novakovic, Aleksandra, Marinko, Marija, Vranic, Aleksandra, Jankovic, Goran, Milojevic, Predrag, Stojanovic, Ivan, Nenezic, Dragoslav, Ugresic, Nenad, Kanjuh, Vladimir, Yang, Qin, He, Guo-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	(-)-Epicatechin Calcium - metabolism Calcium channels Catechin - pharmacology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Extracellular Space - drug effects Extracellular Space - metabolism Human internal mammary artery Humans Intracellular calcium release Intracellular Space - drug effects Intracellular Space - metabolism Male Mammary Arteries - cytology Mammary Arteries - drug effects Mammary Arteries - metabolism Mammary Arteries - physiology Middle Aged Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Phenylephrine - pharmacology Potassium Channel Blockers - pharmacology Potassium channels Potassium Channels - metabolism Vasoconstriction - drug effects Vasodilation - drug effects Vasorelaxation
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