The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia

The opioid and non-opioid types of stress-induced analgesia have been well defined. One of the non-opioid type involve the endocannabinoid system. We previously reported that the spinal serotonin 7 receptor (5-HT7) blockers inhibit both morphine and cannabinoid-induced analgesia, thus we hypothesize...

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Veröffentlicht in:	European journal of pharmacology 2015-09, Vol.762, p.402-410
Hauptverfasser:	Yesilyurt, Ozgur, Seyrek, Melik, Tasdemir, Serdar, Kahraman, Serdar, Deveci, Mehmet Salih, Karakus, Emre, Halici, Zekai, Dogrul, Ahmet
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT7 receptors Animals Behavior, Animal - drug effects Gene Expression Regulation - drug effects Male Mice Mice, Inbred BALB C Pain Perception - drug effects Phenols - pharmacology Receptors, Opioid - metabolism Receptors, Serotonin - genetics Receptors, Serotonin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Serotonergic Neurons - drug effects Serotonergic Neurons - metabolism Serotonergic Neurons - pathology Serotonin Serotonin Antagonists - pharmacology Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology Stress, Psychological - metabolism Stress, Psychological - pathology Stress, Psychological - physiopathology Stress-induced analgesia Sulfonamides - pharmacology
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