Therapeutic hypothermia and hypoxia–ischemia in the term-equivalent neonatal rat: characterization of a translational preclinical model

Background: Hypoxic–ischemic encephalopathy (HIE) is a major cause of morbidity in survivors. Therapeutic hypothermia (TH) is the only available intervention, but the protection is incomplete. Preclinical studies of HIE/TH in the rodent have relied on the postnatal day (P) 7 rat whose brain approxim...

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