Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age

Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age

Background: Anesthesia in early childhood is associated with adverse neurodevelopmental outcome; however, it is not known if age at exposure affects the risk of adverse outcome. Our objective was to evaluate the association of the number and timing of anesthetic exposures for surgery with cognitive...

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Veröffentlicht in:Pediatric research 2015-09, Vol.78 (3), p.323-329
Hauptverfasser: Gano, Dawn, Andersen, Sarah K., Glass, Hannah C., Rogers, Elizabeth E., Glidden, David V., Barkovich, A. James, Ferriero, Donna M.
Format: Artikel
Sprache:eng
Schlagworte:
692/499
Anesthesia - adverse effects
Anesthesia - methods
Brain - surgery
clinical-investigation
Cognition - physiology
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cohort Studies
Developmental Disabilities - diagnosis
Developmental Disabilities - etiology
Female
Follow-Up Studies
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Intelligence Tests
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Regression Analysis
Surgical Procedures, Operative - adverse effects
Surgical Procedures, Operative - methods
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Zusammenfassung:Background: Anesthesia in early childhood is associated with adverse neurodevelopmental outcome; however, it is not known if age at exposure affects the risk of adverse outcome. Our objective was to evaluate the association of the number and timing of anesthetic exposures for surgery with cognitive outcome in a cohort of premature newborns. Methods: A cohort study of exposure to anesthesia for surgery in premature newborns (
ISSN:0031-3998
1530-0447
DOI:10.1038/pr.2015.106