Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells

[Display omitted] Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in various human cancers and has been used as a therapeutic target for tumors. This study screened natural products to identify compounds that inhibit STAT3 activity using a STAT3-dependent lucif...

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Veröffentlicht in:	Biochemical pharmacology 2015-09, Vol.97 (1), p.38-50
Hauptverfasser:	Jung, Seung-Nam, Shin, Dae-Seop, Kim, Hye-Nan, Jeon, Yoon Jung, Yun, Jieun, Lee, Yu-Jin, Kang, Jong Soon, Han, Dong Cho, Kwon, Byoung-Mog
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Carcinoma - drug therapy Carcinoma - enzymology Carcinoma - metabolism Cell Line, Tumor Diterpenes - pharmacology Diterpenes - therapeutic use Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use ERK Female Genes, Reporter - drug effects Humans Male MAP Kinase Signaling System - drug effects Mice, Inbred BALB C Mice, Nude Neoplasm Proteins - agonists Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - enzymology Prostatic Neoplasms - metabolism Protein Tyrosine Phosphatases, Non-Receptor - chemistry Protein Tyrosine Phosphatases, Non-Receptor - metabolism Reactive Oxygen Species - agonists Reactive Oxygen Species - metabolism STAT3 STAT3 Transcription Factor - agonists STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Sugiol Transketolase Transketolase - antagonists & inhibitors Transketolase - chemistry Transketolase - metabolism Tumor Burden - drug effects Xenograft Model Antitumor Assays
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