Cloning and structure of delta-latroinsectotoxin, a novel insect-specific member of the latrotoxin family. Functional expression requires C-terminal truncation

The venom of the black widow spider (BWSV) (Latrodectus mactans tredecimguttatus) contains several potent, high molecular mass (110 kDa) neurotoxins that cause neurotransmitter release in a phylum-specific manner. The molecular mechanism of action of these proteins is poorly understood because their...

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Veröffentlicht in:	The Journal of biological chemistry 1996-03, Vol.271 (13), p.7535-7543
Hauptverfasser:	Dulubova, I.E. (The Rockefeller University, New York, NY.), Krasnoperov, V.G, Khvotchev, M.V, Pluzhnikov, K.A, Volkova, T.M, Grishin, E.V, Vais, H, Bell, D.R, Usherwood, P.N.R
Format:	Artikel
Sprache:	eng
Schlagworte:	ADN Amino Acid Sequence Animals Ankyrins - chemistry Araneae Base Sequence Black Widow Spider - metabolism CLONE CLONES Cloning, Molecular COMPOSICION QUIMICA COMPOSITION CHIMIQUE Consensus Sequence DNA Primers DNA, Complementary Escherichia coli ESTRUCTURA QUIMICA Gene Expression Insecta LATRODECTUS LATRODECTUS MACTANS Lipid Bilayers Mass Spectrometry Membrane Potentials - drug effects Molecular Sequence Data Molecular Weight Muscles - drug effects Muscles - physiology Oligonucleotide Probes Polymerase Chain Reaction Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Sequence Deletion Sequence Homology, Amino Acid SISTEMA NERVIOSO Spider Venoms - biosynthesis Spider Venoms - chemistry Spider Venoms - pharmacology STRUCTURE CHIMIQUE SYSTEME NERVEUX Theridiidae TOXINAS TOXINE VENENOS VENIN
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