The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy

Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development, differentiation and plasticity in both the developing and adult brain. A single-nucleotide polymorphism in the proregion of BDNF, termed the Val66Met polymorphism, results in deficient subcellular translocation and...

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Veröffentlicht in:	Molecular psychiatry 2015-08, Vol.20 (8), p.916-930
Hauptverfasser:	Notaras, M, Hill, R, van den Buuse, M
Format:	Artikel
Sprache:	eng
Schlagworte:	38/43 38/61 59/36 692/699/476/1311 692/699/476/1414 692/699/476/1799 Animals Anxiety Behavioral plasticity Behavioral Sciences Biological Psychology Brain research Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cognition Cognitive ability Developmental plasticity expert-review Gene polymorphism Genetic aspects Genetic diversity Genetic polymorphisms Genetic Predisposition to Disease Genetic research Genetic susceptibility Genetic variance Genotype & phenotype Health aspects Heredity Humans Kinases Medicine Medicine & Public Health Mental disorders Mental Disorders - genetics Mental Disorders - metabolism Mental illness Minority & ethnic groups Mood Nervous system Neurosciences Peptides Pharmacotherapy Polymorphism Polymorphism, Single Nucleotide Proteins Psychiatric research Psychiatry Psychosis Risk factors Single-nucleotide polymorphism Translocation
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