An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS–NRPS is necessary for synthesis of the 2-pyridones, leporins

•An A. flavus hybrid PKS–NRPS produces a family of 2-pyridones, designated leporins.•First description of leporin production in A. flavus.•Leporin overproduction affects A. flavus development.•First description of leporin dimers and the leporin B trimer-iron complex.•A mechanism is proposed for the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Fungal genetics and biology 2015-08, Vol.81, p.88-97
Hauptverfasser:	Cary, Jeffrey W., Uka, Valdet, Han, Zheng, Buyst, Dieter, Harris-Coward, Pamela Y., Ehrlich, Kenneth C., Wei, Qijian, Bhatnagar, Deepak, Dowd, Patrick F., Martens, Stacey L., Calvo, Ana M., Martins, José C., Vanhaecke, Lynn, Coenye, Tom, De Saeger, Sarah, Di Mavungu, José Diana
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus flavus Aspergillus flavus - enzymology Aspergillus flavus - genetics Aspergillus flavus - metabolism Gene cluster Gene Expression Regulation, Fungal High resolution mass spectrometry Leporin Multigene Family Natural products Peptide Synthases - genetics Peptide Synthases - metabolism Pigments, Biological - analysis Polyketide Synthases - genetics Polyketide Synthases - metabolism Pyridones - metabolism Secondary Metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!