Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is a leading cause of death in Asian countries. Sonic hedgehog ( Shh ) pathway plays a role in hepatocarcinogenesis. We investigated the treatment effect of mouse HCC with Shh inhibitor GDC-0449. Methods Mouse hepatoma ML-1 cells were implanted in B...

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Veröffentlicht in:	The American journal of surgery 2015-09, Vol.210 (3), p.554-560
Hauptverfasser:	Jeng, Kuo-Shyang, M.D., F.A.C.S, Jeng, Chi-Juei, M.D, Jeng, Wen-Juei, M.D, Sheen, I-Shyan, M.D, Chang, Chiung-Fang, Ph.D, Hsiau, Hsin-I, M.S, Hung, Zih-Hang, M.S, Yu, Ming-Che, M.S, Chang, Fang-Yu, B.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - pharmacology Animals Antineoplastic Agents - pharmacology Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Confidence intervals Dehydrogenases Down-Regulation GDC-0449 Gene Expression Gli-1 Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Liver cancer Liver Neoplasms, Experimental - drug therapy Liver Neoplasms, Experimental - pathology Male Mice, Inbred C57BL Molecular weight Multivariate analysis Patched Receptors Patched-1 Receptor Polymerase chain reaction Ptch-1 Pyridines - pharmacology Random Allocation Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism RNA, Messenger - metabolism Rodents Shh Smo Smoothened Receptor Sonic hedgehog pathway Surgery Transcription Factors - genetics Transcription Factors - metabolism Tumors Up-Regulation Zinc Finger Protein GLI1
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