Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity
[Display omitted] Dietziamides A and B, two novel tetramic acid dimers, were isolated from the rare actinomycetes Dietzia timorensis MZ-3 in the course of our HPLC-diode array screening of our collection of terrestrial actinomycetes. The spectroscopic analysis revealed the chemical structures of the...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2015-09, Vol.25 (18), p.3953-3955 |
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| container_issue | 18 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 25 |
| creator | Hoshino, Shotaro Wakimoto, Toshiyuki Zhang, Huiping Hayashi, Fumiaki Okada, Masahiro Abe, Ikuro |
| description | [Display omitted]
Dietziamides A and B, two novel tetramic acid dimers, were isolated from the rare actinomycetes Dietzia timorensis MZ-3 in the course of our HPLC-diode array screening of our collection of terrestrial actinomycetes. The spectroscopic analysis revealed the chemical structures of the first secondary metabolites characterized in the genus Dietzia. Dietziamides A and B showed moderate DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities. |
| doi_str_mv | 10.1016/j.bmcl.2015.07.035 |
| format | Article |
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Dietziamides A and B, two novel tetramic acid dimers, were isolated from the rare actinomycetes Dietzia timorensis MZ-3 in the course of our HPLC-diode array screening of our collection of terrestrial actinomycetes. The spectroscopic analysis revealed the chemical structures of the first secondary metabolites characterized in the genus Dietzia. Dietziamides A and B showed moderate DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2015.07.035</identifier><identifier>PMID: 26220156</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Actinomycetales - chemistry ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - metabolism ; Dietzia timorensis ; Dietziamides ; Dimerization ; Lactams - chemistry ; Lactams - isolation & purification ; Lactams - metabolism ; Molecular Structure ; Rare actinomycetes ; Secondary metabolites ; Tetramic acid</subject><ispartof>Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (18), p.3953-3955</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b16ca7a56a7874570a95e7c49561488f5a9d2b8218994f0720252850f2c12ca83</citedby><cites>FETCH-LOGICAL-c356t-b16ca7a56a7874570a95e7c49561488f5a9d2b8218994f0720252850f2c12ca83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X15007398$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26220156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoshino, Shotaro</creatorcontrib><creatorcontrib>Wakimoto, Toshiyuki</creatorcontrib><creatorcontrib>Zhang, Huiping</creatorcontrib><creatorcontrib>Hayashi, Fumiaki</creatorcontrib><creatorcontrib>Okada, Masahiro</creatorcontrib><creatorcontrib>Abe, Ikuro</creatorcontrib><title>Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
Dietziamides A and B, two novel tetramic acid dimers, were isolated from the rare actinomycetes Dietzia timorensis MZ-3 in the course of our HPLC-diode array screening of our collection of terrestrial actinomycetes. The spectroscopic analysis revealed the chemical structures of the first secondary metabolites characterized in the genus Dietzia. Dietziamides A and B showed moderate DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities.</description><subject>Actinomycetales - chemistry</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - metabolism</subject><subject>Dietzia timorensis</subject><subject>Dietziamides</subject><subject>Dimerization</subject><subject>Lactams - chemistry</subject><subject>Lactams - isolation & purification</subject><subject>Lactams - metabolism</subject><subject>Molecular Structure</subject><subject>Rare actinomycetes</subject><subject>Secondary metabolites</subject><subject>Tetramic acid</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrFEEUhQsxmDHmD7iQWrqw21vV9WpwI4maQMSNAcmmqKm-jXfoR6yqmZj8enuY0aWrA5fvHLgfY68F1AKEeb-p12McaglC12BraPQzthLKqKpRoJ-zFbQGKteqH6fsZc4bAKFAqRfsVBq5b5kVC5eE5YnCSB3md3yadzjwgiUtl8hDpI53NGLKvE_zyI80LzTOCadMmX-9qxr-QOUnD1Oh-Td1odAOl-4SVB5fsZM-DBnPj3nGbj9_-n5xVd18-3J98fGmio02pVoLE4MN2gTrrNIWQqvRRtVqI5RzvQ5tJ9dOCte2qgcrQWrpNPQyChmDa87Y28PufZp_bTEXP1KOOAxhwnmbvbCgAZxqzILKAxrTnHPC3t8nGkN69AL8Xq3f-L1av5fkwfpF7VJ6c9zfrkfs_lX-ulyADwcAly93hMnnSDhF7ChhLL6b6X_7fwA_3Inj</recordid><startdate>20150915</startdate><enddate>20150915</enddate><creator>Hoshino, Shotaro</creator><creator>Wakimoto, Toshiyuki</creator><creator>Zhang, Huiping</creator><creator>Hayashi, Fumiaki</creator><creator>Okada, Masahiro</creator><creator>Abe, Ikuro</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150915</creationdate><title>Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity</title><author>Hoshino, Shotaro ; Wakimoto, Toshiyuki ; Zhang, Huiping ; Hayashi, Fumiaki ; Okada, Masahiro ; Abe, Ikuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b16ca7a56a7874570a95e7c49561488f5a9d2b8218994f0720252850f2c12ca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Actinomycetales - chemistry</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - metabolism</topic><topic>Dietzia timorensis</topic><topic>Dietziamides</topic><topic>Dimerization</topic><topic>Lactams - chemistry</topic><topic>Lactams - isolation & purification</topic><topic>Lactams - metabolism</topic><topic>Molecular Structure</topic><topic>Rare actinomycetes</topic><topic>Secondary metabolites</topic><topic>Tetramic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoshino, Shotaro</creatorcontrib><creatorcontrib>Wakimoto, Toshiyuki</creatorcontrib><creatorcontrib>Zhang, Huiping</creatorcontrib><creatorcontrib>Hayashi, Fumiaki</creatorcontrib><creatorcontrib>Okada, Masahiro</creatorcontrib><creatorcontrib>Abe, Ikuro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoshino, Shotaro</au><au>Wakimoto, Toshiyuki</au><au>Zhang, Huiping</au><au>Hayashi, Fumiaki</au><au>Okada, Masahiro</au><au>Abe, Ikuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2015-09-15</date><risdate>2015</risdate><volume>25</volume><issue>18</issue><spage>3953</spage><epage>3955</epage><pages>3953-3955</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>[Display omitted]
Dietziamides A and B, two novel tetramic acid dimers, were isolated from the rare actinomycetes Dietzia timorensis MZ-3 in the course of our HPLC-diode array screening of our collection of terrestrial actinomycetes. The spectroscopic analysis revealed the chemical structures of the first secondary metabolites characterized in the genus Dietzia. Dietziamides A and B showed moderate DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26220156</pmid><doi>10.1016/j.bmcl.2015.07.035</doi><tpages>3</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (18), p.3953-3955 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Actinomycetales - chemistry Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - metabolism Dietzia timorensis Dietziamides Dimerization Lactams - chemistry Lactams - isolation & purification Lactams - metabolism Molecular Structure Rare actinomycetes Secondary metabolites Tetramic acid |
| title | Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity |
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