Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity

[Display omitted] Dietziamides A and B, two novel tetramic acid dimers, were isolated from the rare actinomycetes Dietzia timorensis MZ-3 in the course of our HPLC-diode array screening of our collection of terrestrial actinomycetes. The spectroscopic analysis revealed the chemical structures of the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2015-09, Vol.25 (18), p.3953-3955
Hauptverfasser:	Hoshino, Shotaro, Wakimoto, Toshiyuki, Zhang, Huiping, Hayashi, Fumiaki, Okada, Masahiro, Abe, Ikuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales - chemistry Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - metabolism Dietzia timorensis Dietziamides Dimerization Lactams - chemistry Lactams - isolation & purification Lactams - metabolism Molecular Structure Rare actinomycetes Secondary metabolites Tetramic acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	[Display omitted] Dietziamides A and B, two novel tetramic acid dimers, were isolated from the rare actinomycetes Dietzia timorensis MZ-3 in the course of our HPLC-diode array screening of our collection of terrestrial actinomycetes. The spectroscopic analysis revealed the chemical structures of the first secondary metabolites characterized in the genus Dietzia. Dietziamides A and B showed moderate DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2015.07.035