The effect of dexmedetomidine on the firing properties of STN neurons in Parkinson's disease

Dexmedetomidine (an alpha‐2 adrenergic agonist) sedation is commonly used during subthalamic nucleus (STN) deep‐brain stimulation (DBS). Its effects on the electrophysiological characteristics of human STN neurons are largely unknown. We hypothesised that dexmedetomidine modulates the firing rates a...

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Veröffentlicht in:	The European journal of neuroscience 2015-08, Vol.42 (4), p.2070-2077
Hauptverfasser:	Krishna, Vibhor, Elias, Gavin, Sammartino, Francesco, Basha, Diellor, King, Nicolas K. K., Fasano, Alfonso, Munhoz, Renato, Kalia, Suneil K., Hodaie, Mojgan, Venkatraghavan, Lashmi, Lozano, Andres M., Hutchison, William D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects alpha-2 adrenergic agonist Analgesics, Non-Narcotic - pharmacology beta oscillations burst pattern deep brain stimulation Deep Brain Stimulation - methods Dexmedetomidine - pharmacology Dose-Response Relationship, Drug Female Humans intra-operative sedation Male microelectrode recording Microelectrodes Middle Aged Neurons - drug effects Parkinson Disease - pathology Parkinson Disease - therapy Statistics, Nonparametric Subthalamic Nucleus - cytology Subthalamic Nucleus - physiology
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