Sequence-dependent Induction of Base Pair Substitutions and Frameshifts by Propanodeoxyguanosine during in Vitro DNA Replication

Template primers containing propanodeoxyguanosine (PdG) in two different sequence contexts (C-PdG-C and T-PdG-T) were replicated by the Klenow fragment of DNA polymerase I. The presence of PdG in the template strand reduced the extent of in vitro DNA synthesis 103-104-fold compared with unmodified t...

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Veröffentlicht in:	The Journal of biological chemistry 1996-04, Vol.271 (15), p.9160-9165
Hauptverfasser:	Hashim, Muhammed F., Marnett, Lawrence J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Deoxyguanosine - analogs & derivatives DNA Adducts DNA Damage DNA Replication Kinetics Models, Biological Molecular Sequence Data Mutagenesis Templates, Genetic
Online-Zugang:	Volltext
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