Interactive effects of alcohol and diabetes during pregnancy on the rat fetus
To determine the effect of maternal diabetes and alcohol intake, separately and in combination, on fetal growth and development, pregnant rats were divided into four groups: diabetic (D), diabetic plus alcohol (DA), control (C), and control plus alcohol (CA). Diabetes was induced by administration o...
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| Veröffentlicht in: | Teratogenesis, carcinogenesis, and mutagenesis carcinogenesis, and mutagenesis, 1995, Vol.15 (3), p.147-153 |
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| creator | Lin, Yi Lee, Melvin Leichter, Joseph |
| description | To determine the effect of maternal diabetes and alcohol intake, separately and in combination, on fetal growth and development, pregnant rats were divided into four groups: diabetic (D), diabetic plus alcohol (DA), control (C), and control plus alcohol (CA). Diabetes was induced by administration of streptozotocin before mating and alcohol was administered by gavage (2 g/kg body weight/day) on days 6‐‐11 of gestation. Both diabetic groups (D and DA) had significantly lower weight gain during pregnancy compared to the controls (C and CA), despite the fact that the former consumed more food and water. Alcohol treatment resulted in reduced water and food intake and lower weight gain in the diabetic rats (DA), but not in the non‐diabetic rats (CA), compared to their respective controls (D and C). On day 21 of gestation fetal body weights were significantly less and placental weights were significantly greater in the diabetic groups (D and DA) compared with the non‐diabetic groups (C and CA). Differences in fetal and placental weights between rats exposed and not exposed to alcohol (C vs. CA and D vs. DA) were not significant. The number of fetuses with external malformations was significantly greater in the litters of alcohol exposed diabetic (DA) than non‐alcohol exposed (D) animals. No external or skeletal malformations were observed in fetuses of non‐diabetic rats regardless of whether or not they received alcohol (C or CA). The skeletal development of fetuses of diabetic rats, judged by the number and size of ossification centers on day 21 of gestation, was retarded when compared with fetuses of non‐diabetic rats. Alcohol further retarded skeletal development of fetuses of diabetic animals (DA vs. D), but not of fetuses of non‐diabetic rats (CA vs. C). It is concluded that maternal alcohol administration potentiates the effects of maternal diabetes on the incidence of fetal malformations and the retardation of skeletal development. © 1995 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/tcm.1770150307 |
| format | Article |
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Diabetes was induced by administration of streptozotocin before mating and alcohol was administered by gavage (2 g/kg body weight/day) on days 6‐‐11 of gestation. Both diabetic groups (D and DA) had significantly lower weight gain during pregnancy compared to the controls (C and CA), despite the fact that the former consumed more food and water. Alcohol treatment resulted in reduced water and food intake and lower weight gain in the diabetic rats (DA), but not in the non‐diabetic rats (CA), compared to their respective controls (D and C). On day 21 of gestation fetal body weights were significantly less and placental weights were significantly greater in the diabetic groups (D and DA) compared with the non‐diabetic groups (C and CA). Differences in fetal and placental weights between rats exposed and not exposed to alcohol (C vs. CA and D vs. DA) were not significant. The number of fetuses with external malformations was significantly greater in the litters of alcohol exposed diabetic (DA) than non‐alcohol exposed (D) animals. No external or skeletal malformations were observed in fetuses of non‐diabetic rats regardless of whether or not they received alcohol (C or CA). The skeletal development of fetuses of diabetic rats, judged by the number and size of ossification centers on day 21 of gestation, was retarded when compared with fetuses of non‐diabetic rats. Alcohol further retarded skeletal development of fetuses of diabetic animals (DA vs. D), but not of fetuses of non‐diabetic rats (CA vs. C). It is concluded that maternal alcohol administration potentiates the effects of maternal diabetes on the incidence of fetal malformations and the retardation of skeletal development. © 1995 Wiley‐Liss, Inc.</description><identifier>ISSN: 0270-3211</identifier><identifier>EISSN: 1520-6866</identifier><identifier>DOI: 10.1002/tcm.1770150307</identifier><identifier>PMID: 8584986</identifier><identifier>CODEN: TCMUD8</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Abnormalities, Drug-Induced ; alcohol ; Alcoholism and acute alcohol poisoning ; Animals ; Biological and medical sciences ; Bone Development ; Congenital Abnormalities - etiology ; diabetes ; Diabetes Mellitus, Experimental ; Drinking ; Eating ; Embryonic and Fetal Development ; Ethanol - toxicity ; Female ; fetus ; Litter Size ; malformations ; Medical sciences ; Osteogenesis ; Pregnancy ; Pregnancy in Diabetics ; Rats ; Rats, Sprague-Dawley ; Toxicology</subject><ispartof>Teratogenesis, carcinogenesis, and mutagenesis, 1995, Vol.15 (3), p.147-153</ispartof><rights>Copyright © 1995 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1996 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4387-4d2f6845e618565f917daec4c7731614ec7b6cd6af7b35f1a4cab915f25d94c13</citedby><cites>FETCH-LOGICAL-c4387-4d2f6845e618565f917daec4c7731614ec7b6cd6af7b35f1a4cab915f25d94c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftcm.1770150307$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftcm.1770150307$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2899055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8584986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yi</creatorcontrib><creatorcontrib>Lee, Melvin</creatorcontrib><creatorcontrib>Leichter, Joseph</creatorcontrib><title>Interactive effects of alcohol and diabetes during pregnancy on the rat fetus</title><title>Teratogenesis, carcinogenesis, and mutagenesis</title><addtitle>Teratog. Carcinog. Mutagen</addtitle><description>To determine the effect of maternal diabetes and alcohol intake, separately and in combination, on fetal growth and development, pregnant rats were divided into four groups: diabetic (D), diabetic plus alcohol (DA), control (C), and control plus alcohol (CA). Diabetes was induced by administration of streptozotocin before mating and alcohol was administered by gavage (2 g/kg body weight/day) on days 6‐‐11 of gestation. Both diabetic groups (D and DA) had significantly lower weight gain during pregnancy compared to the controls (C and CA), despite the fact that the former consumed more food and water. Alcohol treatment resulted in reduced water and food intake and lower weight gain in the diabetic rats (DA), but not in the non‐diabetic rats (CA), compared to their respective controls (D and C). On day 21 of gestation fetal body weights were significantly less and placental weights were significantly greater in the diabetic groups (D and DA) compared with the non‐diabetic groups (C and CA). Differences in fetal and placental weights between rats exposed and not exposed to alcohol (C vs. CA and D vs. DA) were not significant. The number of fetuses with external malformations was significantly greater in the litters of alcohol exposed diabetic (DA) than non‐alcohol exposed (D) animals. No external or skeletal malformations were observed in fetuses of non‐diabetic rats regardless of whether or not they received alcohol (C or CA). The skeletal development of fetuses of diabetic rats, judged by the number and size of ossification centers on day 21 of gestation, was retarded when compared with fetuses of non‐diabetic rats. Alcohol further retarded skeletal development of fetuses of diabetic animals (DA vs. D), but not of fetuses of non‐diabetic rats (CA vs. C). It is concluded that maternal alcohol administration potentiates the effects of maternal diabetes on the incidence of fetal malformations and the retardation of skeletal development. © 1995 Wiley‐Liss, Inc.</description><subject>Abnormalities, Drug-Induced</subject><subject>alcohol</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Development</subject><subject>Congenital Abnormalities - etiology</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Experimental</subject><subject>Drinking</subject><subject>Eating</subject><subject>Embryonic and Fetal Development</subject><subject>Ethanol - toxicity</subject><subject>Female</subject><subject>fetus</subject><subject>Litter Size</subject><subject>malformations</subject><subject>Medical sciences</subject><subject>Osteogenesis</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Toxicology</subject><issn>0270-3211</issn><issn>1520-6866</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1v2zAQhomgRep8rNkCcCi6yeHxUxoDo3VSJE2GpB0JijomamTJJam2_vdVYcNBp0433PO-d3gIOQM2B8b4RfarORjDQDHBzAGZgeKs0KXWb8iMccMKwQHekaOUvjMGDIAfksNSlbIq9YzcXvcZo_O5_YkUQ0CfEx0CdZ0fnoeOur6hTetqzJhoM8a2f6LriE-96_2GDj3Nz0ijyzRgHtMJeRtcl_B0N4_J46ePD4ur4uZueb24vCm8FKUpZMODLqVCDaXSKlRgGodeemMEaJDoTa19o10wtVABnPSurkAFrppKehDH5MO2dx2HHyOmbFdt8th1rsdhTBYMk0YyMYHzLejjkFLEYNexXbm4scDsX3928mdf_U2B813zWK-w2eM7YdP-_W7vknddiJOHNu0xXlYVU2rCqi32q-1w85-j9mFx-88LxTbbpoy_91kXX6w2wij77cvSfv18r5aGK7sQfwAfN5em</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Lin, Yi</creator><creator>Lee, Melvin</creator><creator>Leichter, Joseph</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1995</creationdate><title>Interactive effects of alcohol and diabetes during pregnancy on the rat fetus</title><author>Lin, Yi ; Lee, Melvin ; Leichter, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4387-4d2f6845e618565f917daec4c7731614ec7b6cd6af7b35f1a4cab915f25d94c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Abnormalities, Drug-Induced</topic><topic>alcohol</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Development</topic><topic>Congenital Abnormalities - etiology</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Experimental</topic><topic>Drinking</topic><topic>Eating</topic><topic>Embryonic and Fetal Development</topic><topic>Ethanol - toxicity</topic><topic>Female</topic><topic>fetus</topic><topic>Litter Size</topic><topic>malformations</topic><topic>Medical sciences</topic><topic>Osteogenesis</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Toxicology</topic><toplevel>online_resources</toplevel><creatorcontrib>Lin, Yi</creatorcontrib><creatorcontrib>Lee, Melvin</creatorcontrib><creatorcontrib>Leichter, Joseph</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Teratogenesis, carcinogenesis, and mutagenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yi</au><au>Lee, Melvin</au><au>Leichter, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interactive effects of alcohol and diabetes during pregnancy on the rat fetus</atitle><jtitle>Teratogenesis, carcinogenesis, and mutagenesis</jtitle><addtitle>Teratog. Carcinog. Mutagen</addtitle><date>1995</date><risdate>1995</risdate><volume>15</volume><issue>3</issue><spage>147</spage><epage>153</epage><pages>147-153</pages><issn>0270-3211</issn><eissn>1520-6866</eissn><coden>TCMUD8</coden><abstract>To determine the effect of maternal diabetes and alcohol intake, separately and in combination, on fetal growth and development, pregnant rats were divided into four groups: diabetic (D), diabetic plus alcohol (DA), control (C), and control plus alcohol (CA). Diabetes was induced by administration of streptozotocin before mating and alcohol was administered by gavage (2 g/kg body weight/day) on days 6‐‐11 of gestation. Both diabetic groups (D and DA) had significantly lower weight gain during pregnancy compared to the controls (C and CA), despite the fact that the former consumed more food and water. Alcohol treatment resulted in reduced water and food intake and lower weight gain in the diabetic rats (DA), but not in the non‐diabetic rats (CA), compared to their respective controls (D and C). On day 21 of gestation fetal body weights were significantly less and placental weights were significantly greater in the diabetic groups (D and DA) compared with the non‐diabetic groups (C and CA). Differences in fetal and placental weights between rats exposed and not exposed to alcohol (C vs. CA and D vs. DA) were not significant. The number of fetuses with external malformations was significantly greater in the litters of alcohol exposed diabetic (DA) than non‐alcohol exposed (D) animals. No external or skeletal malformations were observed in fetuses of non‐diabetic rats regardless of whether or not they received alcohol (C or CA). The skeletal development of fetuses of diabetic rats, judged by the number and size of ossification centers on day 21 of gestation, was retarded when compared with fetuses of non‐diabetic rats. Alcohol further retarded skeletal development of fetuses of diabetic animals (DA vs. D), but not of fetuses of non‐diabetic rats (CA vs. C). It is concluded that maternal alcohol administration potentiates the effects of maternal diabetes on the incidence of fetal malformations and the retardation of skeletal development. © 1995 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8584986</pmid><doi>10.1002/tcm.1770150307</doi><tpages>7</tpages></addata></record> |
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| subjects | Abnormalities, Drug-Induced alcohol Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Bone Development Congenital Abnormalities - etiology diabetes Diabetes Mellitus, Experimental Drinking Eating Embryonic and Fetal Development Ethanol - toxicity Female fetus Litter Size malformations Medical sciences Osteogenesis Pregnancy Pregnancy in Diabetics Rats Rats, Sprague-Dawley Toxicology |
| title | Interactive effects of alcohol and diabetes during pregnancy on the rat fetus |
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