Glucose-induced inactivation of isocitrate lyase in Saccharomyces cerevisiae is mediated by an internal decapeptide sequence

In this work we have investigated the role of specific peptide sequences for glucose-inactivation of the yeast isocitrate lyase. Thus, different fragments of the ICL1 coding region were fused to the lacZ gene of E. coli to provide a reporter construction. Determinations of β-galactosidase activities...

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Veröffentlicht in:	FEBS letters 1995-07, Vol.367 (3), p.219-222
Hauptverfasser:	Ordiz, Isabel, Herrero, Pilar, Rodicio, Rosaura, Moreno, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Fungal Proteins - antagonists & inhibitors Fungal Proteins - chemistry Glucose - pharmacology Glucose inactivation Glyoxylate cycle Isocitrate Lyase - antagonists & inhibitors Molecular Sequence Data Mutagenesis, Site-Directed Oligonucleotide Probes - chemistry Proteolytic degradation Recombinant Fusion Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Structure-Activity Relationship Yeast
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