Identification of novel pyrazole acid antagonists for the EP sub(1) receptor

The discovery, synthesis and structure-activity relationship (SAR) of a novel series of EP sub(1) receptor antagonists is described. Pyrazole acid 4, identified from a chemical array, had desirable physicochemical properties, an excellent in vitro microsomal inhibition and cytochrome P450 (CYP450) p...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-09, Vol.16 (18), p.4767-4771
Hauptverfasser:	McKeown, Stephen C, Hall, Adrian, Giblin, Gerard MP, Lorthioir, Olivier, Blunt, Richard, Lewell, Xiao Q, Wilson, Richard J, Brown, Susan H, Chowdhury, Anita, Coleman, Tanya, Watson, Stephen P, Chessell, Iain P, Pipe, Adrian, Clayton, Nick, Goldsmith, Paul
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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