Tumorigenic potential of carbaryl in the heterozygous p53 knockout mouse model

The heterozygous p53 knockout mouse model was used to assess whether vascular tumors noted in a 2-year carcinogenicity study in CD-1 mice with carbaryl were induced through a genotoxic mechanism. This knockout mouse model was selected for carbaryl because of the high sensitivity of this model to gen...

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Veröffentlicht in:	Food and chemical toxicology 2003, Vol.41 (1), p.99-106
Hauptverfasser:	Bigot-Lasserre, D, Chuzel, F, Debruyne, E.L.M, Bars, R, Carmichael, N.G
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects animal models Animals Biological and medical sciences Body Weight - drug effects Carbaryl Carbaryl - toxicity Carcinogenesis Carcinogenicity Tests carcinogens Carcinogens - toxicity Cell Transformation, Neoplastic - genetics Disease Models, Animal dosage Dose-Response Relationship, Drug feed intake Genes, p53 - genetics genotoxicity heterozygosity Heterozygous p53 knockout mouse histopathology Insecticides - toxicity Liver - drug effects Male males Medical sciences Mice Mice, Knockout neoplasms No-Observed-Adverse-Effect Level Organ Size - drug effects Pesticides, fertilizers and other agrochemicals toxicology Thymus Gland - drug effects toxicity testing Toxicology Urinary Bladder - drug effects Vascular Neoplasms - chemically induced Vascular Neoplasms - etiology Vascular Neoplasms - genetics vascular tumors Vascular tumours
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