Synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen Trichomonas vaginalis

Synthesis and anti-trichomonas activity of uracil-isatin conjugates. [Display omitted] A library of mono- and bis-uracil isatin conjugates were synthesized and subjected for the assessment of their in vitro activity against the protozoal pathogen Trichomonas vaginalis. The structure activity studies...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2015-08, Vol.23 (16), p.5190-5197
Hauptverfasser:	Kumar, Kewal, Liu, Nicole, Yang, Donald, Na, Daniel, Thompson, John, Wrischnik, Lisa A., Land, Kirkwood M., Kumar, Vipan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Cytotoxicity HeLa Cells Humans Isatin - analogs & derivatives Isatin - chemical synthesis Isatin - pharmacology Structure activity relationship Trichomonas Infections - drug therapy Trichomonas vaginalis Trichomonas vaginalis - drug effects Uracil - analogs & derivatives Uracil - chemical synthesis Uracil - pharmacology Uracil-isatin conjugates
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