mTOR plays an important role in cow's milk allergy-associated behavioral and immunological deficits

Autism spectrum disorder (ASD) is multifactorial, with both genetic as well as environmental factors working in concert to develop the autistic phenotype. Immunological disturbances in autistic individuals have been reported and a role for food allergy has been suggested in ASD. Single gene mutation...

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Veröffentlicht in:	Neuropharmacology 2015-10, Vol.97, p.220-232
Hauptverfasser:	Wu, Jiangbo, de Theije, Caroline G.M., da Silva, Sofia Lopes, van der Horst, Hilma, Reinders, Margot T.M., Broersen, Laus M., Willemsen, Linette E.M., Kas, Martien J.H., Garssen, Johan, Kraneveld, Aletta D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autism spectrum disorder (ASD) Brain - drug effects Brain - metabolism Cattle Chemokine CCL2 - blood Compulsive Behavior - drug therapy Compulsive Behavior - physiopathology Cow's milk allergy (CMA) Diet Disease Models, Animal Grooming - drug effects Grooming - physiology Ileum - drug effects Ileum - metabolism Immunosuppressive Agents - pharmacology Male Mammalian target of rapamycin (mTOR) Mechanistic Target of Rapamycin Complex 1 Mice, Inbred C3H Milk Hypersensitivity - drug therapy Milk Hypersensitivity - physiopathology Milk Hypersensitivity - psychology Multiprotein Complexes - metabolism Rapamycin Regulatory T (Treg) cells RNA, Messenger - metabolism Signal Transduction - drug effects Sirolimus - pharmacology Social Behavior T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - physiology TOR Serine-Threonine Kinases - metabolism
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