Structure of the eukaryotic MCM complex at 3.8 Å

DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in this replication is the assembly of the heterohexameric minichromosome maintenance (MCM2–7) helicase complex at replication origins during G1 phase as an inactive double hexamer. Here, using cryo-electron mi...

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Veröffentlicht in:	Nature (London) 2015-08, Vol.524 (7564), p.186-191
Hauptverfasser:	Li, Ningning, Zhai, Yuanliang, Zhang, Yixiao, Li, Wanqiu, Yang, Maojun, Lei, Jianlin, Tye, Bik-Kwoon, Gao, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/337/151/2353 631/337/151/2355 631/535/1258/1259 82/29 82/80 82/83 Analysis Binding Sites Cell Cycle Proteins - chemistry Cell Cycle Proteins - metabolism Cell Cycle Proteins - ultrastructure Chromatin - chemistry Conserved Sequence Cryoelectron Microscopy Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA - ultrastructure DNA replication DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - ultrastructure Eukaryotes G1 Phase Genetic aspects Humanities and Social Sciences Minichromosome Maintenance Proteins - chemistry Minichromosome Maintenance Proteins - metabolism Minichromosome Maintenance Proteins - ultrastructure Models, Biological Models, Molecular Molecular structure multidisciplinary Multienzyme Complexes - chemistry Multienzyme Complexes - ultrastructure Nucleic Acid Denaturation Physiological aspects Prokaryotes Protein Binding Protein Multimerization Protein Structure, Tertiary Protein Subunits - chemistry Protein Subunits - metabolism Proteins Replication Origin Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - ultrastructure Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Saccharomyces cerevisiae Proteins - ultrastructure Science Yeasts
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