Supramolecular interaction of a cancer cell photosensitizer in the nanocavity of cucurbit[7]uril: A spectroscopic and calorimetric study
[Display omitted] •Interaction of a cancer cell photosensitizer molecule harmane with CB7 was reported.•Emission properties of harmane was modulated several folds in the presence of CB7.•Thermodynamics of the binding was studied by using isothermal titration calorimetry.•Stoichiometry of the complex...
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| Veröffentlicht in: | International journal of pharmaceutics 2015-08, Vol.492 (1-2), p.103-108 |
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| container_title | International journal of pharmaceutics |
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| creator | Ahmed, Sayeed Ashique Chatterjee, Aninda Maity, Banibrata Seth, Debabrata |
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•Interaction of a cancer cell photosensitizer molecule harmane with CB7 was reported.•Emission properties of harmane was modulated several folds in the presence of CB7.•Thermodynamics of the binding was studied by using isothermal titration calorimetry.•Stoichiometry of the complex was found to be 1:1 in the excited state.
The interaction of small biologically active molecules in the nanocavity of supramolecular host is very interesting and thriving research area. In the presence of supramolecular host the absorption and emission properties of small biologically active molecules were modulated several folds compared to bulk solution. In this study we have investigated the supramolecular interaction of a cancer cell photosensitizer molecule harmane in the presence of cucurbit[7]uril (CB7) as host in aqueous buffer solution (pH∼7.2). We have used steady state absorption, emission and time resolved fluorescence spectroscopy techniques. The thermodynamics of the binding between harmane in the nanochannel of CB7 were studied by using isothermal titration calorimetry (ITC) method. The emission properties of harmane are modulated several fold in the presence of CB7. ITC study indicates that the complexation between harmane and CB7 are enthalpically favourable. |
| doi_str_mv | 10.1016/j.ijpharm.2015.07.016 |
| format | Article |
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•Interaction of a cancer cell photosensitizer molecule harmane with CB7 was reported.•Emission properties of harmane was modulated several folds in the presence of CB7.•Thermodynamics of the binding was studied by using isothermal titration calorimetry.•Stoichiometry of the complex was found to be 1:1 in the excited state.
The interaction of small biologically active molecules in the nanocavity of supramolecular host is very interesting and thriving research area. In the presence of supramolecular host the absorption and emission properties of small biologically active molecules were modulated several folds compared to bulk solution. In this study we have investigated the supramolecular interaction of a cancer cell photosensitizer molecule harmane in the presence of cucurbit[7]uril (CB7) as host in aqueous buffer solution (pH∼7.2). We have used steady state absorption, emission and time resolved fluorescence spectroscopy techniques. The thermodynamics of the binding between harmane in the nanochannel of CB7 were studied by using isothermal titration calorimetry (ITC) method. The emission properties of harmane are modulated several fold in the presence of CB7. ITC study indicates that the complexation between harmane and CB7 are enthalpically favourable.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2015.07.016</identifier><identifier>PMID: 26169144</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Bridged-Ring Compounds - chemistry ; Calorimetry ; Cancer cell photosensitizer ; Cucurbituril ; Drug encapsulation ; Fluorescence ; Harmine - analogs & derivatives ; Harmine - chemistry ; Imidazoles - chemistry ; Isothermal titration calorimetry ; Nanostructures - chemistry ; Neoplasms - drug therapy ; Photosensitizing Agents - chemistry ; Spectrometry, Fluorescence</subject><ispartof>International journal of pharmaceutics, 2015-08, Vol.492 (1-2), p.103-108</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-2a24abb1c58de96e968bcd6b315eb45b3f81ff1d93360ec119806b7050ab66893</citedby><cites>FETCH-LOGICAL-c365t-2a24abb1c58de96e968bcd6b315eb45b3f81ff1d93360ec119806b7050ab66893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2015.07.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26169144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Sayeed Ashique</creatorcontrib><creatorcontrib>Chatterjee, Aninda</creatorcontrib><creatorcontrib>Maity, Banibrata</creatorcontrib><creatorcontrib>Seth, Debabrata</creatorcontrib><title>Supramolecular interaction of a cancer cell photosensitizer in the nanocavity of cucurbit[7]uril: A spectroscopic and calorimetric study</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
•Interaction of a cancer cell photosensitizer molecule harmane with CB7 was reported.•Emission properties of harmane was modulated several folds in the presence of CB7.•Thermodynamics of the binding was studied by using isothermal titration calorimetry.•Stoichiometry of the complex was found to be 1:1 in the excited state.
The interaction of small biologically active molecules in the nanocavity of supramolecular host is very interesting and thriving research area. In the presence of supramolecular host the absorption and emission properties of small biologically active molecules were modulated several folds compared to bulk solution. In this study we have investigated the supramolecular interaction of a cancer cell photosensitizer molecule harmane in the presence of cucurbit[7]uril (CB7) as host in aqueous buffer solution (pH∼7.2). We have used steady state absorption, emission and time resolved fluorescence spectroscopy techniques. The thermodynamics of the binding between harmane in the nanochannel of CB7 were studied by using isothermal titration calorimetry (ITC) method. The emission properties of harmane are modulated several fold in the presence of CB7. ITC study indicates that the complexation between harmane and CB7 are enthalpically favourable.</description><subject>Bridged-Ring Compounds - chemistry</subject><subject>Calorimetry</subject><subject>Cancer cell photosensitizer</subject><subject>Cucurbituril</subject><subject>Drug encapsulation</subject><subject>Fluorescence</subject><subject>Harmine - analogs & derivatives</subject><subject>Harmine - chemistry</subject><subject>Imidazoles - chemistry</subject><subject>Isothermal titration calorimetry</subject><subject>Nanostructures - chemistry</subject><subject>Neoplasms - drug therapy</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Spectrometry, Fluorescence</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctq3DAUFaGhmab9hBQtu7ErWbZkd1NCSNpCIIs2q1CEJF8zGmzL0SMw-YJ8dmRm0m3hwoXDOfdxDkIXlJSUUP51V9rdslV-KitCm5KIMqMnaENbwQpWC_4ObQgTbdFQwc7QhxB2hBBeUfYenVWc8o7W9Qa9_E6LV5MbwaRReWznCF6ZaN2M3YAVNmo24LGBccTL1kUXYA422mdYyThuAc9qdkY92bhfJSaZ5LWND-Jv8nb8hi9xWMBE74JxizVYzX2eOjpvJ4g-AyGmfv8RnQ5qDPDp2M_R_c31n6ufxe3dj19Xl7eFYbyJRaWqWmlNTdP20PFcrTY914w2oOtGs6Glw0D7jjFOwFDatYRrQRqiNOdtx87Rl8PcxbvHBCHKyYb1OzWDS0FSQWpWd3VHMrU5UE2-PXgY5JJvVn4vKZFrCHInjyHINQRJhMxo1n0-rkh6gv6f6s31TPh-IEB-9MmCl8FYyD731menZO_sf1a8AvWwnog</recordid><startdate>20150815</startdate><enddate>20150815</enddate><creator>Ahmed, Sayeed Ashique</creator><creator>Chatterjee, Aninda</creator><creator>Maity, Banibrata</creator><creator>Seth, Debabrata</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150815</creationdate><title>Supramolecular interaction of a cancer cell photosensitizer in the nanocavity of cucurbit[7]uril: A spectroscopic and calorimetric study</title><author>Ahmed, Sayeed Ashique ; Chatterjee, Aninda ; Maity, Banibrata ; Seth, Debabrata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-2a24abb1c58de96e968bcd6b315eb45b3f81ff1d93360ec119806b7050ab66893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Bridged-Ring Compounds - chemistry</topic><topic>Calorimetry</topic><topic>Cancer cell photosensitizer</topic><topic>Cucurbituril</topic><topic>Drug encapsulation</topic><topic>Fluorescence</topic><topic>Harmine - analogs & derivatives</topic><topic>Harmine - chemistry</topic><topic>Imidazoles - chemistry</topic><topic>Isothermal titration calorimetry</topic><topic>Nanostructures - chemistry</topic><topic>Neoplasms - drug therapy</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Spectrometry, Fluorescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Sayeed Ashique</creatorcontrib><creatorcontrib>Chatterjee, Aninda</creatorcontrib><creatorcontrib>Maity, Banibrata</creatorcontrib><creatorcontrib>Seth, Debabrata</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Sayeed Ashique</au><au>Chatterjee, Aninda</au><au>Maity, Banibrata</au><au>Seth, Debabrata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supramolecular interaction of a cancer cell photosensitizer in the nanocavity of cucurbit[7]uril: A spectroscopic and calorimetric study</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2015-08-15</date><risdate>2015</risdate><volume>492</volume><issue>1-2</issue><spage>103</spage><epage>108</epage><pages>103-108</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
•Interaction of a cancer cell photosensitizer molecule harmane with CB7 was reported.•Emission properties of harmane was modulated several folds in the presence of CB7.•Thermodynamics of the binding was studied by using isothermal titration calorimetry.•Stoichiometry of the complex was found to be 1:1 in the excited state.
The interaction of small biologically active molecules in the nanocavity of supramolecular host is very interesting and thriving research area. In the presence of supramolecular host the absorption and emission properties of small biologically active molecules were modulated several folds compared to bulk solution. In this study we have investigated the supramolecular interaction of a cancer cell photosensitizer molecule harmane in the presence of cucurbit[7]uril (CB7) as host in aqueous buffer solution (pH∼7.2). We have used steady state absorption, emission and time resolved fluorescence spectroscopy techniques. The thermodynamics of the binding between harmane in the nanochannel of CB7 were studied by using isothermal titration calorimetry (ITC) method. The emission properties of harmane are modulated several fold in the presence of CB7. ITC study indicates that the complexation between harmane and CB7 are enthalpically favourable.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26169144</pmid><doi>10.1016/j.ijpharm.2015.07.016</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Bridged-Ring Compounds - chemistry Calorimetry Cancer cell photosensitizer Cucurbituril Drug encapsulation Fluorescence Harmine - analogs & derivatives Harmine - chemistry Imidazoles - chemistry Isothermal titration calorimetry Nanostructures - chemistry Neoplasms - drug therapy Photosensitizing Agents - chemistry Spectrometry, Fluorescence |
| title | Supramolecular interaction of a cancer cell photosensitizer in the nanocavity of cucurbit[7]uril: A spectroscopic and calorimetric study |
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