Incidence, treatment, and outcome of parotid carcinoma, 1996–2011: a population-based study in Thuringia, Germany
Purpose The objective of this study was to examine patterns of care and survival in a population-based sample of patients with parotid cancer who were treated in Thuringia, a federal state in Germany, between 1996 and 2011. Methods Data of 295 patients with primary parotid cancer from the Thuringian...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2015-09, Vol.141 (9), p.1679-1688 |
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| container_title | Journal of cancer research and clinical oncology |
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| creator | Guntinas-Lichius, Orlando Wendt, Thomas G. Buentzel, Jens Esser, Dirk Böger, Daniel Mueller, Andreas H. Piesold, Jörn-Uwe Schultze-Mosgau, Stefan Schlattmann, Peter Schmalenberg, Harald |
| description | Purpose
The objective of this study was to examine patterns of care and survival in a population-based sample of patients with parotid cancer who were treated in Thuringia, a federal state in Germany, between 1996 and 2011.
Methods
Data of 295 patients with primary parotid cancer from the Thuringian cancer registry were evaluated for patient’s characteristics, tumor stage, incidence, and trends in treatment, cancer-specific survival (CSS), and overall survival (OS).
Results
Stages IV tumors and the amount of tumors in all age cohorts ≥45 years of age increased significantly during the observation period (
p
= 0.002; age all
p
|
| doi_str_mv | 10.1007/s00432-015-1961-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1704348783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1704348783</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-bbe919fac793535ceec98c7f80dd01a23d5009ea07cb847f11c05e0157eef3a93</originalsourceid><addsrcrecordid>eNp1kcFu1TAQRS0Eoo_CB7BBltiweKEeO4ljdqiCUqlSN2VtOfYEUr3YwXYW2fUf-EO-pI5eixBSV9ZY594Z3UvIW2AfgTF5lhirBa8YNBWoFqr1GdnB9gNCNM_JjoGEquHQnpBXKd2yMjeSvyQnvOkYaznsSLr0dnToLe5pjmjyhD7vqfGOhiXbMCENA51NDHl01JpoRx8ms6egVPvn7jdnAJ-ooXOYl4PJY_BVbxI6mvLiVjp6evNziaP_MRbNBcbJ-PU1eTGYQ8I3D-8p-f71y835t-rq-uLy_PNVZeua56rvUYEajJVKNKKxiFZ1Vg4dc46B4cI1jCk0TNq-q-UAYFmDJQyJOAijxCn5cPSdY_i1YMp6GpPFw8F4DEvSIEt8dSc7UdD3_6G3YYm-XLdRZX3Xqo2CI2VjSCnioOc4TiauGpjeGtHHRnQ5Qm-N6LVo3j04L_2E7q_isYIC8COQ5i0njP-sftL1HtIXll8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1703538693</pqid></control><display><type>article</type><title>Incidence, treatment, and outcome of parotid carcinoma, 1996–2011: a population-based study in Thuringia, Germany</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Guntinas-Lichius, Orlando ; Wendt, Thomas G. ; Buentzel, Jens ; Esser, Dirk ; Böger, Daniel ; Mueller, Andreas H. ; Piesold, Jörn-Uwe ; Schultze-Mosgau, Stefan ; Schlattmann, Peter ; Schmalenberg, Harald</creator><creatorcontrib>Guntinas-Lichius, Orlando ; Wendt, Thomas G. ; Buentzel, Jens ; Esser, Dirk ; Böger, Daniel ; Mueller, Andreas H. ; Piesold, Jörn-Uwe ; Schultze-Mosgau, Stefan ; Schlattmann, Peter ; Schmalenberg, Harald</creatorcontrib><description>Purpose
The objective of this study was to examine patterns of care and survival in a population-based sample of patients with parotid cancer who were treated in Thuringia, a federal state in Germany, between 1996 and 2011.
Methods
Data of 295 patients with primary parotid cancer from the Thuringian cancer registry were evaluated for patient’s characteristics, tumor stage, incidence, and trends in treatment, cancer-specific survival (CSS), and overall survival (OS).
Results
Stages IV tumors and the amount of tumors in all age cohorts ≥45 years of age increased significantly during the observation period (
p
= 0.002; age all
p
< 0.05, respectively). The highest increase in crude incidence was observed for salivary duct carcinomas [relative risk per decade (RR) 5.46; 95 % confidence interval (CI) 1.14–26.14] and rare carcinoma subtypes (RR 9.99; 95 % CI 1.85–53.94). CSS at 5 years and at 10 years for all patients was 82.4 and 82.4 %, respectively. OS at 5 years and at 10 years for all patients was 60.1 and 48.2 %, respectively. CSS and OS did not improve over the time. Salivary duct carcinoma showed the lowest 5-year OS (35.6 %). Acinic cell carcinoma had the highest OS rate (85.3 %). Multivariate Cox models revealed that higher grading (G3/G4) was a more powerful independent predictor of decreased OS than TNM stage.
Conclusions
CSS and OS did not improve during the study period. Incidence of parotid cancer increased significantly in elderly patients. It seems that grading is next to patient’s age the better predictor of OS than TNM stage.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-015-1961-y</identifier><identifier>PMID: 25800621</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cancer Research ; Clinical outcomes ; Cohort Studies ; Epidemiology ; Female ; Germany - epidemiology ; Head & neck cancer ; Hematology ; Humans ; Incidence ; Internal Medicine ; Male ; Medical treatment ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Oncology ; Original Article – Clinical Oncology ; Parotid Neoplasms - epidemiology ; Parotid Neoplasms - pathology ; Parotid Neoplasms - therapy ; Registries ; Survival Rate ; Treatment Outcome ; Young Adult</subject><ispartof>Journal of cancer research and clinical oncology, 2015-09, Vol.141 (9), p.1679-1688</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-bbe919fac793535ceec98c7f80dd01a23d5009ea07cb847f11c05e0157eef3a93</citedby><cites>FETCH-LOGICAL-c442t-bbe919fac793535ceec98c7f80dd01a23d5009ea07cb847f11c05e0157eef3a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-015-1961-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-015-1961-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25800621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guntinas-Lichius, Orlando</creatorcontrib><creatorcontrib>Wendt, Thomas G.</creatorcontrib><creatorcontrib>Buentzel, Jens</creatorcontrib><creatorcontrib>Esser, Dirk</creatorcontrib><creatorcontrib>Böger, Daniel</creatorcontrib><creatorcontrib>Mueller, Andreas H.</creatorcontrib><creatorcontrib>Piesold, Jörn-Uwe</creatorcontrib><creatorcontrib>Schultze-Mosgau, Stefan</creatorcontrib><creatorcontrib>Schlattmann, Peter</creatorcontrib><creatorcontrib>Schmalenberg, Harald</creatorcontrib><title>Incidence, treatment, and outcome of parotid carcinoma, 1996–2011: a population-based study in Thuringia, Germany</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
The objective of this study was to examine patterns of care and survival in a population-based sample of patients with parotid cancer who were treated in Thuringia, a federal state in Germany, between 1996 and 2011.
Methods
Data of 295 patients with primary parotid cancer from the Thuringian cancer registry were evaluated for patient’s characteristics, tumor stage, incidence, and trends in treatment, cancer-specific survival (CSS), and overall survival (OS).
Results
Stages IV tumors and the amount of tumors in all age cohorts ≥45 years of age increased significantly during the observation period (
p
= 0.002; age all
p
< 0.05, respectively). The highest increase in crude incidence was observed for salivary duct carcinomas [relative risk per decade (RR) 5.46; 95 % confidence interval (CI) 1.14–26.14] and rare carcinoma subtypes (RR 9.99; 95 % CI 1.85–53.94). CSS at 5 years and at 10 years for all patients was 82.4 and 82.4 %, respectively. OS at 5 years and at 10 years for all patients was 60.1 and 48.2 %, respectively. CSS and OS did not improve over the time. Salivary duct carcinoma showed the lowest 5-year OS (35.6 %). Acinic cell carcinoma had the highest OS rate (85.3 %). Multivariate Cox models revealed that higher grading (G3/G4) was a more powerful independent predictor of decreased OS than TNM stage.
Conclusions
CSS and OS did not improve during the study period. Incidence of parotid cancer increased significantly in elderly patients. It seems that grading is next to patient’s age the better predictor of OS than TNM stage.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer Research</subject><subject>Clinical outcomes</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Head & neck cancer</subject><subject>Hematology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Original Article – Clinical Oncology</subject><subject>Parotid Neoplasms - epidemiology</subject><subject>Parotid Neoplasms - pathology</subject><subject>Parotid Neoplasms - therapy</subject><subject>Registries</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kcFu1TAQRS0Eoo_CB7BBltiweKEeO4ljdqiCUqlSN2VtOfYEUr3YwXYW2fUf-EO-pI5eixBSV9ZY594Z3UvIW2AfgTF5lhirBa8YNBWoFqr1GdnB9gNCNM_JjoGEquHQnpBXKd2yMjeSvyQnvOkYaznsSLr0dnToLe5pjmjyhD7vqfGOhiXbMCENA51NDHl01JpoRx8ms6egVPvn7jdnAJ-ooXOYl4PJY_BVbxI6mvLiVjp6evNziaP_MRbNBcbJ-PU1eTGYQ8I3D-8p-f71y835t-rq-uLy_PNVZeua56rvUYEajJVKNKKxiFZ1Vg4dc46B4cI1jCk0TNq-q-UAYFmDJQyJOAijxCn5cPSdY_i1YMp6GpPFw8F4DEvSIEt8dSc7UdD3_6G3YYm-XLdRZX3Xqo2CI2VjSCnioOc4TiauGpjeGtHHRnQ5Qm-N6LVo3j04L_2E7q_isYIC8COQ5i0njP-sftL1HtIXll8</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Guntinas-Lichius, Orlando</creator><creator>Wendt, Thomas G.</creator><creator>Buentzel, Jens</creator><creator>Esser, Dirk</creator><creator>Böger, Daniel</creator><creator>Mueller, Andreas H.</creator><creator>Piesold, Jörn-Uwe</creator><creator>Schultze-Mosgau, Stefan</creator><creator>Schlattmann, Peter</creator><creator>Schmalenberg, Harald</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150901</creationdate><title>Incidence, treatment, and outcome of parotid carcinoma, 1996–2011: a population-based study in Thuringia, Germany</title><author>Guntinas-Lichius, Orlando ; Wendt, Thomas G. ; Buentzel, Jens ; Esser, Dirk ; Böger, Daniel ; Mueller, Andreas H. ; Piesold, Jörn-Uwe ; Schultze-Mosgau, Stefan ; Schlattmann, Peter ; Schmalenberg, Harald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-bbe919fac793535ceec98c7f80dd01a23d5009ea07cb847f11c05e0157eef3a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer Research</topic><topic>Clinical outcomes</topic><topic>Cohort Studies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Head & neck cancer</topic><topic>Hematology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Original Article – Clinical Oncology</topic><topic>Parotid Neoplasms - epidemiology</topic><topic>Parotid Neoplasms - pathology</topic><topic>Parotid Neoplasms - therapy</topic><topic>Registries</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guntinas-Lichius, Orlando</creatorcontrib><creatorcontrib>Wendt, Thomas G.</creatorcontrib><creatorcontrib>Buentzel, Jens</creatorcontrib><creatorcontrib>Esser, Dirk</creatorcontrib><creatorcontrib>Böger, Daniel</creatorcontrib><creatorcontrib>Mueller, Andreas H.</creatorcontrib><creatorcontrib>Piesold, Jörn-Uwe</creatorcontrib><creatorcontrib>Schultze-Mosgau, Stefan</creatorcontrib><creatorcontrib>Schlattmann, Peter</creatorcontrib><creatorcontrib>Schmalenberg, Harald</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guntinas-Lichius, Orlando</au><au>Wendt, Thomas G.</au><au>Buentzel, Jens</au><au>Esser, Dirk</au><au>Böger, Daniel</au><au>Mueller, Andreas H.</au><au>Piesold, Jörn-Uwe</au><au>Schultze-Mosgau, Stefan</au><au>Schlattmann, Peter</au><au>Schmalenberg, Harald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence, treatment, and outcome of parotid carcinoma, 1996–2011: a population-based study in Thuringia, Germany</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>141</volume><issue>9</issue><spage>1679</spage><epage>1688</epage><pages>1679-1688</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
The objective of this study was to examine patterns of care and survival in a population-based sample of patients with parotid cancer who were treated in Thuringia, a federal state in Germany, between 1996 and 2011.
Methods
Data of 295 patients with primary parotid cancer from the Thuringian cancer registry were evaluated for patient’s characteristics, tumor stage, incidence, and trends in treatment, cancer-specific survival (CSS), and overall survival (OS).
Results
Stages IV tumors and the amount of tumors in all age cohorts ≥45 years of age increased significantly during the observation period (
p
= 0.002; age all
p
< 0.05, respectively). The highest increase in crude incidence was observed for salivary duct carcinomas [relative risk per decade (RR) 5.46; 95 % confidence interval (CI) 1.14–26.14] and rare carcinoma subtypes (RR 9.99; 95 % CI 1.85–53.94). CSS at 5 years and at 10 years for all patients was 82.4 and 82.4 %, respectively. OS at 5 years and at 10 years for all patients was 60.1 and 48.2 %, respectively. CSS and OS did not improve over the time. Salivary duct carcinoma showed the lowest 5-year OS (35.6 %). Acinic cell carcinoma had the highest OS rate (85.3 %). Multivariate Cox models revealed that higher grading (G3/G4) was a more powerful independent predictor of decreased OS than TNM stage.
Conclusions
CSS and OS did not improve during the study period. Incidence of parotid cancer increased significantly in elderly patients. It seems that grading is next to patient’s age the better predictor of OS than TNM stage.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25800621</pmid><doi>10.1007/s00432-015-1961-y</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2015-09, Vol.141 (9), p.1679-1688 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Cancer Research Clinical outcomes Cohort Studies Epidemiology Female Germany - epidemiology Head & neck cancer Hematology Humans Incidence Internal Medicine Male Medical treatment Medicine Medicine & Public Health Middle Aged Neoplasm Staging Oncology Original Article – Clinical Oncology Parotid Neoplasms - epidemiology Parotid Neoplasms - pathology Parotid Neoplasms - therapy Registries Survival Rate Treatment Outcome Young Adult |
| title | Incidence, treatment, and outcome of parotid carcinoma, 1996–2011: a population-based study in Thuringia, Germany |
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