Establishment of primary patient‐derived xenografts of palliative TURP specimens to study castrate‐resistant prostate cancer

BACKGROUND Fresh patient specimens of castrate‐resistant prostate cancer (CRPC) are invaluable for studying tumor heterogeneity and responses to current treatments. They can be used for primary patient‐derived xenografts (PDXs) or serially transplantable PDXs, but only a small proportion of samples...

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Veröffentlicht in:	The Prostate 2015-09, Vol.75 (13), p.1475-1483
Hauptverfasser:	Lawrence, Mitchell G., Pook, David W., Wang, Hong, Porter, Laura H., Frydenberg, Mark, Kourambas, John, Appu, Sree, Poole, Christine, Beardsley, Emma K., Ryan, Andrew, Norden, Sam, Papargiris, Melissa M., Risbridger, Gail P., Taylor, Renea A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over androgen Animals castrate‐resistance Heterografts Humans Male Mice Neoplasm Transplantation - methods prostate cancer Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Transplantation, Heterologous - methods Transurethral Resection of Prostate TURP xenograft
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