Synthesis and in Vivo Evaluation of [123I]Melanin-Targeted Agents

This study reports the synthesis, [123I]­radiolabeling, and biological profile of a new series of iodinated compounds for potential translation to the corresponding [131I]­radiolabeled compounds for radionuclide therapy of melanoma. Radiolabeling was achieved via standard electrophilic iododestannyl...

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Veröffentlicht in:	Journal of medicinal chemistry 2015-08, Vol.58 (15), p.6214-6224
Hauptverfasser:	Roberts, Maxine P, Nguyen, Vu, Ashford, Mark E, Berghofer, Paula, Wyatt, Naomi A, Krause-Heuer, Anwen M, Pham, Tien Q, Taylor, Stephen R, Hogan, Leena, Jiang, Cathy D, Fraser, Benjamin H, Lengkeek, Nigel A, Matesic, Lidia, Gregoire, Marie-Claude, Denoyer, Delphine, Hicks, Rodney J, Katsifis, Andrew, Greguric, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Iodine Radioisotopes - chemistry Iodine Radioisotopes - therapeutic use Melanins - chemistry Melanoma - radiotherapy Mice Mice, Inbred C57BL Tomography, Emission-Computed, Single-Photon
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