Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications

[Display omitted] The primary purpose of this study was to process partially hydrolyzed PVOH grades (degree of hydroxylation (DH): 33–88%) via HME and to evaluate them as carrier for oral immediate release dosage forms in order to improve the release rate of poorly water soluble drugs (i.e., HCT and...

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Veröffentlicht in:	International journal of pharmaceutics 2015-08, Vol.492 (1-2), p.1-9
Hauptverfasser:	De Jaeghere, W., De Beer, T., Van Bocxlaer, J., Remon, J.P., Vervaet, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological Availability Celecoxib - blood Celecoxib - chemistry Celecoxib - pharmacokinetics Dogs Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Compounding Drug Liberation Hot Temperature Hot-melt extrusion Hydrochlorothiazide - chemistry Hydrogen-Ion Concentration Hydrolysis Immediate release Oral drug delivery Osmolar Concentration Polyvinyl alcohol Polyvinyl Alcohol - chemistry Polyvinyl Alcohol - pharmacokinetics Supersaturation
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