Autologous, Noncultured Epidermal Cell Suspension Grafting in the Management of Mechanically and Chemically Induced Leukodermic Scars
Background: Melanocyte-keratinocyte transplant procedure (MKTP) successfully repigments postburn leukodermic scars. Objective: To further investigate the efficacy and limitations of MKTP for treatment of mechanically and chemically induced leukodermic scars. Methods: Ten patients with mechanically o...
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| Veröffentlicht in: | Journal of cutaneous medicine and surgery 2015-09, Vol.19 (5), p.488-493 |
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| container_title | Journal of cutaneous medicine and surgery |
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| creator | Vyas, Nikki S. Lawrence, Kelsey L. Griffith, James L. Hamzavi, Iltefat H. |
| description | Background:
Melanocyte-keratinocyte transplant procedure (MKTP) successfully repigments postburn leukodermic scars.
Objective:
To further investigate the efficacy and limitations of MKTP for treatment of mechanically and chemically induced leukodermic scars.
Methods:
Ten patients with mechanically or chemically induced, depigmented or hypopigmented scars were preoperatively evaluated with Wood’s light examination, treated with MKTP, and followed for at least 6 months, with monitoring of repigmentation and colour matching.
Results:
Nine patients attended at least 6 months of follow-up. Six patients showed no fluorescence of scars under Wood’s lamp. All patients whose lesions didn’t fluoresce displayed less than 50% repigmentation, with 5 of 6 attaining 0% to 24%. Of the 3 patients displaying bright or some fluorescence, more than 95% repigmentation was achieved in 2 patients (skin phototypes V and VI), while less than 24% was attained for the third (skin phototype II).
Conclusions:
In this small case series, lack of fluorescence in leukodermic scars may be a useful negative prognostic indicator for MKTP, but additional trials are needed to verify that this is not due to melanocompetency. |
| doi_str_mv | 10.1177/1203475415581311 |
| format | Article |
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Melanocyte-keratinocyte transplant procedure (MKTP) successfully repigments postburn leukodermic scars.
Objective:
To further investigate the efficacy and limitations of MKTP for treatment of mechanically and chemically induced leukodermic scars.
Methods:
Ten patients with mechanically or chemically induced, depigmented or hypopigmented scars were preoperatively evaluated with Wood’s light examination, treated with MKTP, and followed for at least 6 months, with monitoring of repigmentation and colour matching.
Results:
Nine patients attended at least 6 months of follow-up. Six patients showed no fluorescence of scars under Wood’s lamp. All patients whose lesions didn’t fluoresce displayed less than 50% repigmentation, with 5 of 6 attaining 0% to 24%. Of the 3 patients displaying bright or some fluorescence, more than 95% repigmentation was achieved in 2 patients (skin phototypes V and VI), while less than 24% was attained for the third (skin phototype II).
Conclusions:
In this small case series, lack of fluorescence in leukodermic scars may be a useful negative prognostic indicator for MKTP, but additional trials are needed to verify that this is not due to melanocompetency.</description><identifier>ISSN: 1203-4754</identifier><identifier>EISSN: 1615-7109</identifier><identifier>DOI: 10.1177/1203475415581311</identifier><identifier>PMID: 25851083</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Cell Transplantation - methods ; Cicatrix - therapy ; Female ; Humans ; Keratinocytes - transplantation ; Male ; Melanocytes - transplantation ; Middle Aged ; Prospective Studies ; Skin Pigmentation - physiology ; Transplantation, Autologous</subject><ispartof>Journal of cutaneous medicine and surgery, 2015-09, Vol.19 (5), p.488-493</ispartof><rights>The Author(s) 2015</rights><rights>The Author(s) 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-732e2cb447e972d82d8c1850815ad032d313508b3037b38f31393a63b5762b6a3</citedby><cites>FETCH-LOGICAL-c365t-732e2cb447e972d82d8c1850815ad032d313508b3037b38f31393a63b5762b6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1203475415581311$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1203475415581311$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25851083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vyas, Nikki S.</creatorcontrib><creatorcontrib>Lawrence, Kelsey L.</creatorcontrib><creatorcontrib>Griffith, James L.</creatorcontrib><creatorcontrib>Hamzavi, Iltefat H.</creatorcontrib><title>Autologous, Noncultured Epidermal Cell Suspension Grafting in the Management of Mechanically and Chemically Induced Leukodermic Scars</title><title>Journal of cutaneous medicine and surgery</title><addtitle>J Cutan Med Surg</addtitle><description>Background:
Melanocyte-keratinocyte transplant procedure (MKTP) successfully repigments postburn leukodermic scars.
Objective:
To further investigate the efficacy and limitations of MKTP for treatment of mechanically and chemically induced leukodermic scars.
Methods:
Ten patients with mechanically or chemically induced, depigmented or hypopigmented scars were preoperatively evaluated with Wood’s light examination, treated with MKTP, and followed for at least 6 months, with monitoring of repigmentation and colour matching.
Results:
Nine patients attended at least 6 months of follow-up. Six patients showed no fluorescence of scars under Wood’s lamp. All patients whose lesions didn’t fluoresce displayed less than 50% repigmentation, with 5 of 6 attaining 0% to 24%. Of the 3 patients displaying bright or some fluorescence, more than 95% repigmentation was achieved in 2 patients (skin phototypes V and VI), while less than 24% was attained for the third (skin phototype II).
Conclusions:
In this small case series, lack of fluorescence in leukodermic scars may be a useful negative prognostic indicator for MKTP, but additional trials are needed to verify that this is not due to melanocompetency.</description><subject>Adult</subject><subject>Cell Transplantation - methods</subject><subject>Cicatrix - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Keratinocytes - transplantation</subject><subject>Male</subject><subject>Melanocytes - transplantation</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Skin Pigmentation - physiology</subject><subject>Transplantation, Autologous</subject><issn>1203-4754</issn><issn>1615-7109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9P4zAQxS0EAhb2zglZ4sJhw3rsOE6PqOJPpcIeyp4jx5m0gcQudnzgA_C911ULKyEhWbKf5jfP9htCzoBdASj1GzgTuZI5SFmCANgjx1CAzBSwyX46p3K2qR-RHyE8M8YAZH5IjrgsJbBSHJP36zi63i1dDL_oo7Mm9mP02NCbddegH3RPp9j3dBHDGm3onKV3XrdjZ5e0s3RcIX3QVi9xQDtS19IHNCttO6P7_o1q29DpCoednNkmmuQ9x_jiNu6doQujfTglB63uA_7c7Sfk7-3N0_Q-m_-5m02v55kRhRwzJThyU-e5woniTZmWgVKyEqRumOCNAJFULZhQtSjbJCdCF6KWquB1ocUJudz6rr17jRjGauiCSf_TFlMCFSiWp0DzskjoxRf02UVv0-sqDjIhUnCZKLaljHcheGyrte8G7d8qYNVmRNXXEaWW851xrAdsPhs-ZpKAbAuEFOv_W781_AdTPZeu</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Vyas, Nikki S.</creator><creator>Lawrence, Kelsey L.</creator><creator>Griffith, James L.</creator><creator>Hamzavi, Iltefat H.</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>Autologous, Noncultured Epidermal Cell Suspension Grafting in the Management of Mechanically and Chemically Induced Leukodermic Scars</title><author>Vyas, Nikki S. ; Lawrence, Kelsey L. ; Griffith, James L. ; Hamzavi, Iltefat H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-732e2cb447e972d82d8c1850815ad032d313508b3037b38f31393a63b5762b6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Cell Transplantation - methods</topic><topic>Cicatrix - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Keratinocytes - transplantation</topic><topic>Male</topic><topic>Melanocytes - transplantation</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Skin Pigmentation - physiology</topic><topic>Transplantation, Autologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vyas, Nikki S.</creatorcontrib><creatorcontrib>Lawrence, Kelsey L.</creatorcontrib><creatorcontrib>Griffith, James L.</creatorcontrib><creatorcontrib>Hamzavi, Iltefat H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vyas, Nikki S.</au><au>Lawrence, Kelsey L.</au><au>Griffith, James L.</au><au>Hamzavi, Iltefat H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autologous, Noncultured Epidermal Cell Suspension Grafting in the Management of Mechanically and Chemically Induced Leukodermic Scars</atitle><jtitle>Journal of cutaneous medicine and surgery</jtitle><addtitle>J Cutan Med Surg</addtitle><date>2015-09</date><risdate>2015</risdate><volume>19</volume><issue>5</issue><spage>488</spage><epage>493</epage><pages>488-493</pages><issn>1203-4754</issn><eissn>1615-7109</eissn><abstract>Background:
Melanocyte-keratinocyte transplant procedure (MKTP) successfully repigments postburn leukodermic scars.
Objective:
To further investigate the efficacy and limitations of MKTP for treatment of mechanically and chemically induced leukodermic scars.
Methods:
Ten patients with mechanically or chemically induced, depigmented or hypopigmented scars were preoperatively evaluated with Wood’s light examination, treated with MKTP, and followed for at least 6 months, with monitoring of repigmentation and colour matching.
Results:
Nine patients attended at least 6 months of follow-up. Six patients showed no fluorescence of scars under Wood’s lamp. All patients whose lesions didn’t fluoresce displayed less than 50% repigmentation, with 5 of 6 attaining 0% to 24%. Of the 3 patients displaying bright or some fluorescence, more than 95% repigmentation was achieved in 2 patients (skin phototypes V and VI), while less than 24% was attained for the third (skin phototype II).
Conclusions:
In this small case series, lack of fluorescence in leukodermic scars may be a useful negative prognostic indicator for MKTP, but additional trials are needed to verify that this is not due to melanocompetency.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>25851083</pmid><doi>10.1177/1203475415581311</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| subjects | Adult Cell Transplantation - methods Cicatrix - therapy Female Humans Keratinocytes - transplantation Male Melanocytes - transplantation Middle Aged Prospective Studies Skin Pigmentation - physiology Transplantation, Autologous |
| title | Autologous, Noncultured Epidermal Cell Suspension Grafting in the Management of Mechanically and Chemically Induced Leukodermic Scars |
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