ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis

Actin is a regulator of synaptic vesicle mobilization and exocytosis, but little is known about the mechanisms that regulate actin at presynaptic terminals. Genetic data on LIMK1, a negative regulator of actin-depolymerizing proteins of the ADF/cofilin family, suggest a role for ADF/cofilin in presy...

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Veröffentlicht in:	Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2015-09, Vol.25 (9), p.2863-2875
Hauptverfasser:	Wolf, Michael, Zimmermann, Anika-Maria, Görlich, Andreas, Gurniak, Christine B, Sassoè-Pognetto, Marco, Friauf, Eckhard, Witke, Walter, Rust, Marco B
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Cofilin 1 - genetics Cofilin 1 - metabolism Destrin - genetics Destrin - metabolism Electric Stimulation Excitatory Postsynaptic Potentials - genetics Excitatory Postsynaptic Potentials - physiology Exocytosis - drug effects Exocytosis - genetics Exocytosis - physiology Glutamic Acid - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Mice Mice, Transgenic Mutation - genetics Neurons - drug effects Neurons - physiology Neurons - ultrastructure Phosphorylation Potassium Chloride - pharmacology Prosencephalon - cytology Protein Transport - genetics Protein Transport - physiology SNARE Proteins - metabolism Synapses - drug effects Synapses - physiology Synapses - ultrastructure Synaptic Vesicles - metabolism
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