Metabolism of promutagens catalyzed by Drosophila melanogaster CYP6A2 enzyme in Saccharomyces cerevisiae

The somatic mutation and recombination test (SMART) in Drosophila melanogaster allows screening of chemicals for genotoxicity in a multicellular organism. In order to correlate data obtained in the SMART with those from genotoxicity tests in rodents, it is important to learn more on the variety of d...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1996, Vol.27 (1), p.46-58
Hauptverfasser:	Saner, Catherine, Weibel, Beatrice, Würgler, Friedrich E., Sengstag, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - pharmacokinetics Aflatoxin B1 - pharmacokinetics Amino Acid Sequence Animals Base Sequence Biological and medical sciences Biotransformation - genetics Carbolines - pharmacokinetics Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytotoxicity Drosophila melanogaster Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Enzyme Induction Escherichia coli - genetics Fundamental and applied biological sciences. Psychology gene conversion Gene Conversion - drug effects Gene Expression Regulation, Developmental Genes, Insect Genes, Synthetic Genes. Genome Humans insecticide resistance Introns Larva Microsomes - enzymology Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenicity Tests Mutagens - pharmacokinetics NADPH-cytochrome P450 oxidoreductase NADPH-Ferrihemoprotein Reductase - genetics NADPH-Ferrihemoprotein Reductase - metabolism Organ Specificity Prodrugs - pharmacokinetics Recombinant Fusion Proteins - metabolism recombination test Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism xenobiotic metabolism
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