Antitumor Effect of c-myc Antisense Phosphorothioate Oligodeoxynucleotides on Human Melanoma Cells In Vitro and in Mice

Background Phosphorothioate oligodeoxynucleotides ([S]ODNs) contain a modified internucleoside phosphate backbone. Antisense [S] ODNs targeted to specific oncogenes have been used with some therapeutic success in animal models of human leukemia; however, the potential for antisense [S]ODN treatment...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1996-04, Vol.88 (7), p.419-429
Hauptverfasser:	Leonetti, Carlo, D' Agnano, Igea, Lozupone, Francesco, Valentini, Alessandra, Geiser, Tim, Zon, Gerald, Calabretta, Bruno, Citro, Gennaro, Zupi, Gabriella
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Apoptosis - drug effects Base Sequence Biochemistry Biological and medical sciences Blotting, Western Cell Cycle - drug effects Cell Division - drug effects Cellular biology Drug Administration Schedule Flow Cytometry Genes Genes, myc Humans Medical research Medical sciences Melanoma - drug therapy Melanoma - pathology Mice Mice, Nude Molecular Sequence Data Oligonucleotides, Antisense - therapeutic use Other treatments Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics RNA, Messenger - metabolism Rodents Skin cancer Thionucleotides Time Factors Transplantation, Heterologous Treatment. General aspects Tumor Cells, Cultured Tumors
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