Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochrome c

Chromatin is pivotal for regulation of the DNA damage process insofar as it influences access to DNA and serves as a DNA repair docking site. Recent works identify histone chaperones as key regulators of damaged chromatin's transcriptional activity. However, understanding how chaperones are mod...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-08, Vol.112 (32), p.9908-9913
Hauptverfasser:	Gonzalez-Arzola, Katiuska, Diaz-Moreno, Irene, Cano-Gonzalez, Ana, Diaz-Quintana, Antonio, Velazquez-Campoy, Adrian, Moreno-Beltran, Blas, Lopez-Rivas, Abelardo, De la Rosa, Miguel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive - drug effects Biological Sciences Camptothecin - pharmacology Cell Nucleus - drug effects Cell Nucleus - metabolism Cytochromes c - chemistry Cytochromes c - metabolism DNA Damage HeLa Cells Histone Chaperones - antagonists & inhibitors Histone Chaperones - chemistry Histone Chaperones - metabolism Histones - metabolism Humans Magnetic Resonance Spectroscopy Models, Molecular Molecular Chaperones - antagonists & inhibitors Molecular Chaperones - chemistry Molecular Chaperones - metabolism Protein Binding - drug effects Protein Structure, Tertiary Protein Transport - drug effects Structure-Activity Relationship Transcription Factors - antagonists & inhibitors Transcription Factors - chemistry Transcription Factors - metabolism Xenopus
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