Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial

IMPORTANCE: Testosterone use in older men is increasing, but its long-term effects on progression of atherosclerosis are unknown. OBJECTIVE: To determine the effect of testosterone administration on subclinical atherosclerosis progression in older men with low or low-normal testosterone levels. DESI...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2015-08, Vol.314 (6), p.570-581
Hauptverfasser:	Basaria, Shehzad, Harman, S. Mitchell, Travison, Thomas G, Hodis, Howard, Tsitouras, Panayiotis, Budoff, Matthew, Pencina, Karol M, Vita, Joseph, Dzekov, Connie, Mazer, Norman A, Coviello, Andrea D, Knapp, Philip E, Hally, Kathleen, Pinjic, Emma, Yan, Mingzhu, Storer, Thomas W, Bhasin, Shalender
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Atherosclerosis Atherosclerosis - chemically induced Calcium - analysis Carotid Intima-Media Thickness Clinical trials Coronary Vessels - chemistry Disease Progression Double-Blind Method Health Status Humans Hypertension Male Mens health Middle Aged Obesity Older people Quality of Life Sexual Dysfunction, Physiological - complications Sexual Dysfunction, Physiological - etiology Testosterone Testosterone - adverse effects Testosterone - blood Testosterone - deficiency Testosterone - therapeutic use Treatment Outcome
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Zusammenfassung:	IMPORTANCE: Testosterone use in older men is increasing, but its long-term effects on progression of atherosclerosis are unknown. OBJECTIVE: To determine the effect of testosterone administration on subclinical atherosclerosis progression in older men with low or low-normal testosterone levels. DESIGN, SETTING, AND PARTICIPANTS: Testosterone’s Effects on Atherosclerosis Progression in Aging Men (TEAAM) was a placebo-controlled, double-blind, parallel-group randomized trial involving 308 men 60 years or older with low or low-normal testosterone levels (100-400 ng/dL; free testosterone
ISSN:	0098-7484 1538-3598
DOI:	10.1001/jama.2015.8881