Upregulation of interleukin-1β/transforming growth factor-β1 and hypoxia relate to molecular mechanisms underlying immobilization-induced muscle contracture

ABSTRACT Introduction: In this study we investigated the molecular mechanism underlying muscle contracture in rats. Methods: The rats were divided into immobilization and control groups, and soleus muscles of the right and left sides were selected for analyses. Results: The levels of CD11b and α‐SMA...

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Veröffentlicht in:	Muscle & nerve 2015-09, Vol.52 (3), p.419-427
Hauptverfasser:	Honda, Yuichiro, Sakamoto, Junya, Nakano, Jiro, Kataoka, Hideki, Sasabe, Ryo, Goto, Kyo, Tanaka, Miho, Origuchi, Tomoki, Yoshimura, Toshiro, Okita, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals CD11b Antigen - metabolism Collagen Type I - genetics Collagen Type I - metabolism Collagen Type III - genetics Collagen Type III - metabolism Contracture - etiology Contracture - metabolism fibrosis Gene Expression Regulation hypoxia Hypoxia - genetics Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - genetics IL-1β Immobilization - adverse effects Interleukin-1beta - genetics muscle contracture Muscle, Skeletal - metabolism Rats RNA, Messenger - metabolism TGF-β1 Transforming Growth Factor beta1 - genetics Up-Regulation
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