Inhibition of myeloid cell leukemia-1: Association with sorafenib-induced apoptosis in human mucoepidermoid carcinoma cells and tumor xenograft

Background The purpose of our study was to investigate the anticancer effect of sorafenib on mucoepidermoid carcinoma (MEC) and find its new molecular mechanism. Methods The apoptotic effects of sorafenib were performed using MTS assay, diamidino‐phenylindole (DAPI) staining, Western blotting, rever...

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Veröffentlicht in:	Head & neck 2015-09, Vol.37 (9), p.1326-1335
Hauptverfasser:	Yu, Hyun-Ju, Shin, Ji-Ae, Jung, Ji-Youn, Nam, Jeong-Seok, Hong, In-Sun, Cho, Nam-Pyo, Cho, Sung-Dae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects Apoptosis - genetics Blotting, Western Carcinoma, Mucoepidermoid - drug therapy Carcinoma, Mucoepidermoid - pathology Cell Proliferation - drug effects Disease Models, Animal Down-Regulation Female Heterografts - drug effects Heterografts - pathology Humans Mice Mice, Nude mucoepidermoid carcinoma Myeloid Cell Leukemia Sequence 1 Protein - genetics myeloid cell leukemia-1 (Mcl-1) Niacinamide - analogs & derivatives Niacinamide - pharmacology Phenylurea Compounds - pharmacology Random Allocation Real-Time Polymerase Chain Reaction RNA, Small Interfering - metabolism Salivary Gland Neoplasms - drug therapy Salivary Gland Neoplasms - pathology Sensitivity and Specificity signal transducer and activator of transcription 3 (STAT3) Signal Transduction sorafenib Tumor Cells, Cultured
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