Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts
Aims Ciliated hepatic foregut cysts (CHFCs) are retained benign lesions of the liver. However, a case of squamous cell metaplasia and five cases of squamous cell carcinoma arising from a CHFC have been described. The potential of malignant transformation makes the identification of new biomarkers ne...
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| Veröffentlicht in: | Histopathology 2015-09, Vol.67 (3), p.398-403 |
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| container_title | Histopathology |
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| creator | Grizzi, Fabio Franceschini, Barbara Di Biccari, Sonia Musardo, Stefano Pedretti, Elisa Chiriva-Internati, Maurizio Osipov, Vladimir Fernández-Aceñero, Maria J |
| description | Aims
Ciliated hepatic foregut cysts (CHFCs) are retained benign lesions of the liver. However, a case of squamous cell metaplasia and five cases of squamous cell carcinoma arising from a CHFC have been described. The potential of malignant transformation makes the identification of new biomarkers necessary. As the cancer/testis antigen sperm protein 17 (Sp17) has been detected in oral and oesophageal squamous cell carcinomas, the aim of this study was to investigate the expression of Sp17 and AKAP‐associated sperm protein (ASP), which has a shared N‐terminal sequence with Sp17, in four surgically resected CHFCs.
Methods and results
CHFC specimens were taken from two patients who attended the Medical College of Wisconsin, Milwaukee, USA and two patients who attended the Fundación Jiménez Díaz, Madrid, Spain. CHFCs were found to be immunopositive for Sp17 and ASP. Both proteins were localized to the cytoplasm of ciliated cells lining the cysts, and their cilia. Confocal microscopy demonstrated that Sp17 and ASP overlapped in the same region of the cell.
Conclusion
Sp17 and ASP cancer/testis antigens were found in ciliated cells of four CHFCs. Further characterization of Sp17 and ASP in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas. |
| doi_str_mv | 10.1111/his.12654 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1703698534</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1703698534</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4244-4fab87e1ef31a008360ff8c5e8c9fc63cd48ab81c0687f9fa0cb897b1b6d688a3</originalsourceid><addsrcrecordid>eNp10V1rFDEUBuAgil2rF_4BGfBGL6abTCYfc7ks2haXurCK4E3IZE7a1NmZac4Mdv-9aactKJibBPKclwMvIW8ZPWHpLK8CnrBCivIZWTAuRV4IUT0nC8pplVMm1RF5hXhNKVO8KF6So0JImj7lghx2A8R9NsR-hNBlTGW2a7LVl9U2t4i9C3aEJsO_kLOdg7gcAceAyY_hErr0iJDB7RABMY3cudDO41cw2DG4zPcRLqcxcwcc8TV54W2L8ObhPibfP3_6tj7LN19Pz9erTe7Koizz0ttaK2DgObOUai6p99oJ0K7yTnLXlDoJ5qjUylfeUlfrStWslo3U2vJj8mHOTevfTGlnsw_ooG1tB_2EhinKZaUFLxN9_w-97qfYpe3uFS0VVSKpj7NysUeM4M0Qw97Gg2HU3PVhUh_mvo9k3z0kTvUemif5WEACyxn8Di0c_p9kzs53j5H5PBFwhNunCRt_Gam4EubHxam52P5cV5vtzgj-B79cpJE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1703047075</pqid></control><display><type>article</type><title>Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Grizzi, Fabio ; Franceschini, Barbara ; Di Biccari, Sonia ; Musardo, Stefano ; Pedretti, Elisa ; Chiriva-Internati, Maurizio ; Osipov, Vladimir ; Fernández-Aceñero, Maria J</creator><creatorcontrib>Grizzi, Fabio ; Franceschini, Barbara ; Di Biccari, Sonia ; Musardo, Stefano ; Pedretti, Elisa ; Chiriva-Internati, Maurizio ; Osipov, Vladimir ; Fernández-Aceñero, Maria J</creatorcontrib><description>Aims
Ciliated hepatic foregut cysts (CHFCs) are retained benign lesions of the liver. However, a case of squamous cell metaplasia and five cases of squamous cell carcinoma arising from a CHFC have been described. The potential of malignant transformation makes the identification of new biomarkers necessary. As the cancer/testis antigen sperm protein 17 (Sp17) has been detected in oral and oesophageal squamous cell carcinomas, the aim of this study was to investigate the expression of Sp17 and AKAP‐associated sperm protein (ASP), which has a shared N‐terminal sequence with Sp17, in four surgically resected CHFCs.
Methods and results
CHFC specimens were taken from two patients who attended the Medical College of Wisconsin, Milwaukee, USA and two patients who attended the Fundación Jiménez Díaz, Madrid, Spain. CHFCs were found to be immunopositive for Sp17 and ASP. Both proteins were localized to the cytoplasm of ciliated cells lining the cysts, and their cilia. Confocal microscopy demonstrated that Sp17 and ASP overlapped in the same region of the cell.
Conclusion
Sp17 and ASP cancer/testis antigens were found in ciliated cells of four CHFCs. Further characterization of Sp17 and ASP in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.12654</identifier><identifier>PMID: 25600306</identifier><identifier>CODEN: HISTDD</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adaptor Proteins, Signal Transducing - metabolism ; Adult ; AKAP-associated sperm protein ; Antigens, Surface - metabolism ; Autoantigens - metabolism ; biomarkers ; Biomarkers - metabolism ; Carcinoma, Squamous Cell - etiology ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Carrier Proteins - metabolism ; Cell Transformation, Neoplastic ; cilia ; Cilia - pathology ; ciliated hepatic foregut cysts ; Cysts - metabolism ; Cysts - pathology ; Female ; Humans ; Immunohistochemistry ; Liver Diseases - metabolism ; Liver Diseases - pathology ; Liver Neoplasms - etiology ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Male ; Metaplasia - metabolism ; Metaplasia - pathology ; Middle Aged ; sperm protein 17 ; squamous cell carcinoma</subject><ispartof>Histopathology, 2015-09, Vol.67 (3), p.398-403</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4244-4fab87e1ef31a008360ff8c5e8c9fc63cd48ab81c0687f9fa0cb897b1b6d688a3</citedby><cites>FETCH-LOGICAL-c4244-4fab87e1ef31a008360ff8c5e8c9fc63cd48ab81c0687f9fa0cb897b1b6d688a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhis.12654$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhis.12654$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25600306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grizzi, Fabio</creatorcontrib><creatorcontrib>Franceschini, Barbara</creatorcontrib><creatorcontrib>Di Biccari, Sonia</creatorcontrib><creatorcontrib>Musardo, Stefano</creatorcontrib><creatorcontrib>Pedretti, Elisa</creatorcontrib><creatorcontrib>Chiriva-Internati, Maurizio</creatorcontrib><creatorcontrib>Osipov, Vladimir</creatorcontrib><creatorcontrib>Fernández-Aceñero, Maria J</creatorcontrib><title>Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
Ciliated hepatic foregut cysts (CHFCs) are retained benign lesions of the liver. However, a case of squamous cell metaplasia and five cases of squamous cell carcinoma arising from a CHFC have been described. The potential of malignant transformation makes the identification of new biomarkers necessary. As the cancer/testis antigen sperm protein 17 (Sp17) has been detected in oral and oesophageal squamous cell carcinomas, the aim of this study was to investigate the expression of Sp17 and AKAP‐associated sperm protein (ASP), which has a shared N‐terminal sequence with Sp17, in four surgically resected CHFCs.
Methods and results
CHFC specimens were taken from two patients who attended the Medical College of Wisconsin, Milwaukee, USA and two patients who attended the Fundación Jiménez Díaz, Madrid, Spain. CHFCs were found to be immunopositive for Sp17 and ASP. Both proteins were localized to the cytoplasm of ciliated cells lining the cysts, and their cilia. Confocal microscopy demonstrated that Sp17 and ASP overlapped in the same region of the cell.
Conclusion
Sp17 and ASP cancer/testis antigens were found in ciliated cells of four CHFCs. Further characterization of Sp17 and ASP in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas.</description><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Adult</subject><subject>AKAP-associated sperm protein</subject><subject>Antigens, Surface - metabolism</subject><subject>Autoantigens - metabolism</subject><subject>biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Transformation, Neoplastic</subject><subject>cilia</subject><subject>Cilia - pathology</subject><subject>ciliated hepatic foregut cysts</subject><subject>Cysts - metabolism</subject><subject>Cysts - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Liver Diseases - metabolism</subject><subject>Liver Diseases - pathology</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Metaplasia - metabolism</subject><subject>Metaplasia - pathology</subject><subject>Middle Aged</subject><subject>sperm protein 17</subject><subject>squamous cell carcinoma</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10V1rFDEUBuAgil2rF_4BGfBGL6abTCYfc7ks2haXurCK4E3IZE7a1NmZac4Mdv-9aactKJibBPKclwMvIW8ZPWHpLK8CnrBCivIZWTAuRV4IUT0nC8pplVMm1RF5hXhNKVO8KF6So0JImj7lghx2A8R9NsR-hNBlTGW2a7LVl9U2t4i9C3aEJsO_kLOdg7gcAceAyY_hErr0iJDB7RABMY3cudDO41cw2DG4zPcRLqcxcwcc8TV54W2L8ObhPibfP3_6tj7LN19Pz9erTe7Koizz0ttaK2DgObOUai6p99oJ0K7yTnLXlDoJ5qjUylfeUlfrStWslo3U2vJj8mHOTevfTGlnsw_ooG1tB_2EhinKZaUFLxN9_w-97qfYpe3uFS0VVSKpj7NysUeM4M0Qw97Gg2HU3PVhUh_mvo9k3z0kTvUemif5WEACyxn8Di0c_p9kzs53j5H5PBFwhNunCRt_Gam4EubHxam52P5cV5vtzgj-B79cpJE</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Grizzi, Fabio</creator><creator>Franceschini, Barbara</creator><creator>Di Biccari, Sonia</creator><creator>Musardo, Stefano</creator><creator>Pedretti, Elisa</creator><creator>Chiriva-Internati, Maurizio</creator><creator>Osipov, Vladimir</creator><creator>Fernández-Aceñero, Maria J</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts</title><author>Grizzi, Fabio ; Franceschini, Barbara ; Di Biccari, Sonia ; Musardo, Stefano ; Pedretti, Elisa ; Chiriva-Internati, Maurizio ; Osipov, Vladimir ; Fernández-Aceñero, Maria J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4244-4fab87e1ef31a008360ff8c5e8c9fc63cd48ab81c0687f9fa0cb897b1b6d688a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Adult</topic><topic>AKAP-associated sperm protein</topic><topic>Antigens, Surface - metabolism</topic><topic>Autoantigens - metabolism</topic><topic>biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell Transformation, Neoplastic</topic><topic>cilia</topic><topic>Cilia - pathology</topic><topic>ciliated hepatic foregut cysts</topic><topic>Cysts - metabolism</topic><topic>Cysts - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Liver Diseases - metabolism</topic><topic>Liver Diseases - pathology</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Metaplasia - metabolism</topic><topic>Metaplasia - pathology</topic><topic>Middle Aged</topic><topic>sperm protein 17</topic><topic>squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grizzi, Fabio</creatorcontrib><creatorcontrib>Franceschini, Barbara</creatorcontrib><creatorcontrib>Di Biccari, Sonia</creatorcontrib><creatorcontrib>Musardo, Stefano</creatorcontrib><creatorcontrib>Pedretti, Elisa</creatorcontrib><creatorcontrib>Chiriva-Internati, Maurizio</creatorcontrib><creatorcontrib>Osipov, Vladimir</creatorcontrib><creatorcontrib>Fernández-Aceñero, Maria J</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grizzi, Fabio</au><au>Franceschini, Barbara</au><au>Di Biccari, Sonia</au><au>Musardo, Stefano</au><au>Pedretti, Elisa</au><au>Chiriva-Internati, Maurizio</au><au>Osipov, Vladimir</au><au>Fernández-Aceñero, Maria J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2015-09</date><risdate>2015</risdate><volume>67</volume><issue>3</issue><spage>398</spage><epage>403</epage><pages>398-403</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><coden>HISTDD</coden><abstract>Aims
Ciliated hepatic foregut cysts (CHFCs) are retained benign lesions of the liver. However, a case of squamous cell metaplasia and five cases of squamous cell carcinoma arising from a CHFC have been described. The potential of malignant transformation makes the identification of new biomarkers necessary. As the cancer/testis antigen sperm protein 17 (Sp17) has been detected in oral and oesophageal squamous cell carcinomas, the aim of this study was to investigate the expression of Sp17 and AKAP‐associated sperm protein (ASP), which has a shared N‐terminal sequence with Sp17, in four surgically resected CHFCs.
Methods and results
CHFC specimens were taken from two patients who attended the Medical College of Wisconsin, Milwaukee, USA and two patients who attended the Fundación Jiménez Díaz, Madrid, Spain. CHFCs were found to be immunopositive for Sp17 and ASP. Both proteins were localized to the cytoplasm of ciliated cells lining the cysts, and their cilia. Confocal microscopy demonstrated that Sp17 and ASP overlapped in the same region of the cell.
Conclusion
Sp17 and ASP cancer/testis antigens were found in ciliated cells of four CHFCs. Further characterization of Sp17 and ASP in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25600306</pmid><doi>10.1111/his.12654</doi><tpages>6</tpages></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing - metabolism Adult AKAP-associated sperm protein Antigens, Surface - metabolism Autoantigens - metabolism biomarkers Biomarkers - metabolism Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carrier Proteins - metabolism Cell Transformation, Neoplastic cilia Cilia - pathology ciliated hepatic foregut cysts Cysts - metabolism Cysts - pathology Female Humans Immunohistochemistry Liver Diseases - metabolism Liver Diseases - pathology Liver Neoplasms - etiology Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Metaplasia - metabolism Metaplasia - pathology Middle Aged sperm protein 17 squamous cell carcinoma |
| title | Sperm protein 17 and AKAP-associated sperm protein cancer/testis antigens are expressed in ciliated hepatic foregut cysts |
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