Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade
NEUROPROTECTION against 100μM veratridine-induced cell death and inhibition of voltage-dependent sodium currents by phenytoin, carbamazepine, lidocaine and vinpocetine were studied in rat primary cerebrocortical cultures. Neuroprotective efficacies and sodium channel blocking potencies of these drug...
Gespeichert in:
| Veröffentlicht in: | Neuroreport 1995-12, Vol.7 (1), p.89-92 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 92 |
|---|---|
| container_issue | 1 |
| container_start_page | 89 |
| container_title | Neuroreport |
| container_volume | 7 |
| creator | Lakics, Viktor Molnár, Péter Erdö, Sándor L |
| description | NEUROPROTECTION against 100μM veratridine-induced cell death and inhibition of voltage-dependent sodium currents by phenytoin, carbamazepine, lidocaine and vinpocetine were studied in rat primary cerebrocortical cultures. Neuroprotective efficacies and sodium channel blocking potencies of these drugs failed to show a correlation, suggesting that (i) mechanisms other than sodium channel blockade may be involved in the neuroprotection, and/or (ii) inhibitory efficacy against veratridine-and voltage-activated channels may differ remarkably. |
| doi_str_mv | 10.1097/00001756-199512000-00021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17036793</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17036793</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3601-2661471e097b7a0e636be545ec946c27d23b0feb5ef8d46fb11f93cde1dffc853</originalsourceid><addsrcrecordid>eNp1kc9PHCEUgEmjsavtn9CEQ-NtFIYBht6MsT8SEz1o4o0wzKNLZYcVmFr_e9nuujchhMD7HvA-EMKUnFGi5DmpjUouGqoUp21dNXW09ANa0E6yhvP-4QAtiOKq6ZTgH9Fxzn8qogjtj9BRL7u29gXytykWsMXHCZvfxk-54L-QTEl-9BPgEv9568sL9hOuu9jGVLw1Ads5lDlB_oYTBLPJz0u_rjzOcfTzCtulmSYIeAjRPpoRPqFDZ0KGz7v5BN1_v7q7_Nlc3_z4dXlx3VgmCG1aIWoFFGqVgzQEBBMD8I6DVZ2wrRxbNhAHAwfXj51wA6VOMTsCHZ2zPWcn6HR77jrFpxly0SufLYRgJohz1lQSJqRiFey3oE0x5wROr5NfmfSiKdEby_rNst5b1v8t19QvuzvmYQXjPnGntca_7uImV1kumcn6vMda1Xey3Ty122LPMRRI-THMz5D0EkwoS_3eH7NX_M2Wnw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17036793</pqid></control><display><type>article</type><title>Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Lakics, Viktor ; Molnár, Péter ; Erdö, Sándor L</creator><creatorcontrib>Lakics, Viktor ; Molnár, Péter ; Erdö, Sándor L</creatorcontrib><description>NEUROPROTECTION against 100μM veratridine-induced cell death and inhibition of voltage-dependent sodium currents by phenytoin, carbamazepine, lidocaine and vinpocetine were studied in rat primary cerebrocortical cultures. Neuroprotective efficacies and sodium channel blocking potencies of these drugs failed to show a correlation, suggesting that (i) mechanisms other than sodium channel blockade may be involved in the neuroprotection, and/or (ii) inhibitory efficacy against veratridine-and voltage-activated channels may differ remarkably.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199512000-00021</identifier><identifier>PMID: 8742424</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Biological and medical sciences ; Carbamazepine - pharmacology ; Cell Death - drug effects ; Cells, Cultured ; Cerebral Cortex - drug effects ; Cerebral Cortex - pathology ; Lidocaine - pharmacology ; Medical sciences ; Neuropharmacology ; Neuroprotective agent ; Neuroprotective Agents - pharmacology ; Patch-Clamp Techniques ; Pharmacology. Drug treatments ; Phenytoin - pharmacology ; Rats ; Rats, Sprague-Dawley ; Sodium Channel Blockers ; Veratridine - antagonists & inhibitors ; Veratridine - toxicity ; Vinca Alkaloids - pharmacology</subject><ispartof>Neuroreport, 1995-12, Vol.7 (1), p.89-92</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2984725$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8742424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lakics, Viktor</creatorcontrib><creatorcontrib>Molnár, Péter</creatorcontrib><creatorcontrib>Erdö, Sándor L</creatorcontrib><title>Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>NEUROPROTECTION against 100μM veratridine-induced cell death and inhibition of voltage-dependent sodium currents by phenytoin, carbamazepine, lidocaine and vinpocetine were studied in rat primary cerebrocortical cultures. Neuroprotective efficacies and sodium channel blocking potencies of these drugs failed to show a correlation, suggesting that (i) mechanisms other than sodium channel blockade may be involved in the neuroprotection, and/or (ii) inhibitory efficacy against veratridine-and voltage-activated channels may differ remarkably.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbamazepine - pharmacology</subject><subject>Cell Death - drug effects</subject><subject>Cells, Cultured</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - pathology</subject><subject>Lidocaine - pharmacology</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Patch-Clamp Techniques</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenytoin - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sodium Channel Blockers</subject><subject>Veratridine - antagonists & inhibitors</subject><subject>Veratridine - toxicity</subject><subject>Vinca Alkaloids - pharmacology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9PHCEUgEmjsavtn9CEQ-NtFIYBht6MsT8SEz1o4o0wzKNLZYcVmFr_e9nuujchhMD7HvA-EMKUnFGi5DmpjUouGqoUp21dNXW09ANa0E6yhvP-4QAtiOKq6ZTgH9Fxzn8qogjtj9BRL7u29gXytykWsMXHCZvfxk-54L-QTEl-9BPgEv9568sL9hOuu9jGVLw1Ads5lDlB_oYTBLPJz0u_rjzOcfTzCtulmSYIeAjRPpoRPqFDZ0KGz7v5BN1_v7q7_Nlc3_z4dXlx3VgmCG1aIWoFFGqVgzQEBBMD8I6DVZ2wrRxbNhAHAwfXj51wA6VOMTsCHZ2zPWcn6HR77jrFpxly0SufLYRgJohz1lQSJqRiFey3oE0x5wROr5NfmfSiKdEby_rNst5b1v8t19QvuzvmYQXjPnGntca_7uImV1kumcn6vMda1Xey3Ty122LPMRRI-THMz5D0EkwoS_3eH7NX_M2Wnw</recordid><startdate>19951229</startdate><enddate>19951229</enddate><creator>Lakics, Viktor</creator><creator>Molnár, Péter</creator><creator>Erdö, Sándor L</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19951229</creationdate><title>Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade</title><author>Lakics, Viktor ; Molnár, Péter ; Erdö, Sándor L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3601-2661471e097b7a0e636be545ec946c27d23b0feb5ef8d46fb11f93cde1dffc853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbamazepine - pharmacology</topic><topic>Cell Death - drug effects</topic><topic>Cells, Cultured</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - pathology</topic><topic>Lidocaine - pharmacology</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Patch-Clamp Techniques</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenytoin - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sodium Channel Blockers</topic><topic>Veratridine - antagonists & inhibitors</topic><topic>Veratridine - toxicity</topic><topic>Vinca Alkaloids - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lakics, Viktor</creatorcontrib><creatorcontrib>Molnár, Péter</creatorcontrib><creatorcontrib>Erdö, Sándor L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakics, Viktor</au><au>Molnár, Péter</au><au>Erdö, Sándor L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1995-12-29</date><risdate>1995</risdate><volume>7</volume><issue>1</issue><spage>89</spage><epage>92</epage><pages>89-92</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>NEUROPROTECTION against 100μM veratridine-induced cell death and inhibition of voltage-dependent sodium currents by phenytoin, carbamazepine, lidocaine and vinpocetine were studied in rat primary cerebrocortical cultures. Neuroprotective efficacies and sodium channel blocking potencies of these drugs failed to show a correlation, suggesting that (i) mechanisms other than sodium channel blockade may be involved in the neuroprotection, and/or (ii) inhibitory efficacy against veratridine-and voltage-activated channels may differ remarkably.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8742424</pmid><doi>10.1097/00001756-199512000-00021</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 1995-12, Vol.7 (1), p.89-92 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17036793 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Biological and medical sciences Carbamazepine - pharmacology Cell Death - drug effects Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - pathology Lidocaine - pharmacology Medical sciences Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacology Patch-Clamp Techniques Pharmacology. Drug treatments Phenytoin - pharmacology Rats Rats, Sprague-Dawley Sodium Channel Blockers Veratridine - antagonists & inhibitors Veratridine - toxicity Vinca Alkaloids - pharmacology |
| title | Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T12%3A45%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protection%20against%20veratridine%20toxicity%20in%20rat%20cortical%20cultures:%20relationship%20to%20sodium%20channel%20blockade&rft.jtitle=Neuroreport&rft.au=Lakics,%20Viktor&rft.date=1995-12-29&rft.volume=7&rft.issue=1&rft.spage=89&rft.epage=92&rft.pages=89-92&rft.issn=0959-4965&rft.eissn=1473-558X&rft_id=info:doi/10.1097/00001756-199512000-00021&rft_dat=%3Cproquest_cross%3E17036793%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17036793&rft_id=info:pmid/8742424&rfr_iscdi=true |