Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade

NEUROPROTECTION against 100μM veratridine-induced cell death and inhibition of voltage-dependent sodium currents by phenytoin, carbamazepine, lidocaine and vinpocetine were studied in rat primary cerebrocortical cultures. Neuroprotective efficacies and sodium channel blocking potencies of these drug...

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Veröffentlicht in:	Neuroreport 1995-12, Vol.7 (1), p.89-92
Hauptverfasser:	Lakics, Viktor, Molnár, Péter, Erdö, Sándor L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carbamazepine - pharmacology Cell Death - drug effects Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - pathology Lidocaine - pharmacology Medical sciences Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacology Patch-Clamp Techniques Pharmacology. Drug treatments Phenytoin - pharmacology Rats Rats, Sprague-Dawley Sodium Channel Blockers Veratridine - antagonists & inhibitors Veratridine - toxicity Vinca Alkaloids - pharmacology
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Zusammenfassung:	NEUROPROTECTION against 100μM veratridine-induced cell death and inhibition of voltage-dependent sodium currents by phenytoin, carbamazepine, lidocaine and vinpocetine were studied in rat primary cerebrocortical cultures. Neuroprotective efficacies and sodium channel blocking potencies of these drugs failed to show a correlation, suggesting that (i) mechanisms other than sodium channel blockade may be involved in the neuroprotection, and/or (ii) inhibitory efficacy against veratridine-and voltage-activated channels may differ remarkably.
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-199512000-00021