Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF

The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and NPFF2, were isolated from human and rat central nervous system tissues. NPFF specifically bound to NPFF1 (Kd = 1.13 nm) and N...

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Veröffentlicht in:	The Journal of biological chemistry 2000-12, Vol.275 (50), p.39324-39331
Hauptverfasser:	Bonini, James A., Jones, Kenneth A., Adham, Nika, Forray, Carlos, Artymyshyn, Roman, Durkin, Margaret M., Smith, Kelli E., Tamm, Joseph A., Boteju, Lakmal W., Lakhlani, Parul P., Raddatz, Rita, Yao, Wen-Jeng, Ogozalek, Kristine L., Boyle, Noel, Kouranova, Evguenia V., Quan, Yong, Vaysse, Pierre J., Wetzel, John M., Branchek, Theresa A., Gerald, Christophe, Borowsky, Beth
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Arginine - analogs & derivatives Arginine - metabolism Binding Sites Brain - metabolism Calcium - metabolism Chromosome Mapping Cloning, Molecular COS Cells Cyclic AMP - metabolism DNA, Complementary - metabolism Electrophysiology Gene Library Humans Kinetics Ligands Molecular Sequence Data neuropeptide FF Oligopeptides - metabolism Oocytes Phosphatidylinositols - metabolism Protein Binding Protein Structure, Tertiary Rats Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Receptors, Neuropeptide - biosynthesis Receptors, Neuropeptide - chemistry Receptors, Neuropeptide - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sequence Homology, Amino Acid Tissue Distribution Xenopus
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