Olfactory Reciprocal Synapses: Dendritic Signaling in the CNS
Synaptic transmission between dendrites in the olfactory bulb is thought to play a major role in the processing of olfactory information. Glutamate released from mitral cell dendrites excites the dendrites of granule cells, which in turn mediate GABAergic dendrodendritic inhibition back onto mitral...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1998-04, Vol.20 (4), p.749-761 |
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| creator | Isaacson, Jeffry S. Strowbridge, Ben W. |
| description | Synaptic transmission between dendrites in the olfactory bulb is thought to play a major role in the processing of olfactory information. Glutamate released from mitral cell dendrites excites the dendrites of granule cells, which in turn mediate GABAergic dendrodendritic inhibition back onto mitral dendrites. We examined the mechanisms governing reciprocal dendritic transmission in rat olfactory bulb slices. We find that NMDA receptors play a critical role in this dendrodendritic inhibition. As with axonic synapses, the dendritic release of fast neurotransmitters relies on N- and P/Q-type calcium channels. The magnitude of dendrodendritic transmission is directly proportional to dendritic calcium influx. Furthermore, recordings from pairs of mitral cells show that dendrodendritic synapses can mediate lateral inhibition independently of axonal action potentials. |
| doi_str_mv | 10.1016/S0896-6273(00)81013-2 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 2-Amino-5-phosphonovalerate - pharmacology Animals Axons - physiology Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels - drug effects Calcium Channels - physiology Dendrites - drug effects Dendrites - physiology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Glycine - pharmacology In Vitro Techniques mitral cells Models, Neurological Nifedipine - pharmacology Olfactory Bulb - physiology omega-Conotoxin GVIA omega-Conotoxins Patch-Clamp Techniques Peptides - pharmacology Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - physiology Signal Transduction - physiology Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Tetrodotoxin - pharmacology |
| title | Olfactory Reciprocal Synapses: Dendritic Signaling in the CNS |
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