Inhibition by carbamazepine of various ion channels-mediated catecholamine secretion in cultured bovine adrenal medullary cells

The effects of carbamazepine (CBZ) on 22Na+ influx, 45Ca2- influx, catecholamine secretion and cyclic GMP production were examined in cultured bovine adrenal medullary cells. 1) CBZ (40-120 mumol/l) inhibited 22Na+ influx evoked by carbachol in a concentration-dependent manner. CBZ inhibited carbach...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1995-09, Vol.352 (3), p.297-301
Hauptverfasser:	Yoshimura, R, Yanagihara, N, Terao, T, Minami, K, Abe, K, Izumi, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Medulla - cytology Adrenal Medulla - drug effects Animals Anticonvulsants - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology Carbamazepine - pharmacology Cattle Cells, Cultured Cyclic GMP - metabolism Dose-Response Relationship, Drug Drug Interactions Drug Synergism Epinephrine - metabolism Ion Channels - drug effects Muscarine - pharmacology Nitrendipine - pharmacology Norepinephrine - metabolism omega-Agatoxin IVA Potassium - pharmacology Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism Sodium - metabolism Spider Venoms - pharmacology Veratridine - pharmacology
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