Increase In Interleukin-6 Serum Level Preceding Fever In Granulocytopenia And Correlation With Death From Sepsis
Serum interleukin (IL)-6Ievels measured by ELISA were correlated with the clinical course of 53 adults with hematologic malignancies in 95 episodes of chemotherapy-induced leukocytopenia (< 1000/µL). The median IL-6 level was 15 pg/ml, (range, < 3–123) in 27 episodes without fever. This level...
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| Veröffentlicht in: | The Journal of infectious diseases 1995-01, Vol.171 (1), p.225-228 |
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| creator | Tilman Steinmetz, H. Herbertz, Annette Bertram, Monika Diehl, Volker |
| description | Serum interleukin (IL)-6Ievels measured by ELISA were correlated with the clinical course of 53 adults with hematologic malignancies in 95 episodes of chemotherapy-induced leukocytopenia (< 1000/µL). The median IL-6 level was 15 pg/ml, (range, < 3–123) in 27 episodes without fever. This level was 14.5 pg/ml, (range, < 3–187) 72–48 h before onset of fever, 78 pg/mL (range, < 3–170) 24 h before fever in episodes with unexplained fever (FDO), and 182 pg/mL (range, 63–1076) 24 h before fever in episodes with positive blood cultures (P < .001). Within 24 h after onset of fever, median IL-6 level was 171 pg/ml, (range, 53–1134) in episodes of FDO, 444 pg/ml, (range, 38–7973) in episodes with gram-negative bacteremia, and 2017 pg/ml, (range, 76–7253) with gram-positive bacteremia (P < .01). IL-6 levels increased before death in all 13 patients who died of sepsis. Median level was 7253 pg/mL (range, 445–95,906) within 3 days of death. Determination of IL-6 may be useful for early assessment and as a prognostic tool in leukocytopenic fever. |
| doi_str_mv | 10.1093/infdis/171.1.225 |
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The median IL-6 level was 15 pg/ml, (range, < 3–123) in 27 episodes without fever. This level was 14.5 pg/ml, (range, < 3–187) 72–48 h before onset of fever, 78 pg/mL (range, < 3–170) 24 h before fever in episodes with unexplained fever (FDO), and 182 pg/mL (range, 63–1076) 24 h before fever in episodes with positive blood cultures (P < .001). Within 24 h after onset of fever, median IL-6 level was 171 pg/ml, (range, 53–1134) in episodes of FDO, 444 pg/ml, (range, 38–7973) in episodes with gram-negative bacteremia, and 2017 pg/ml, (range, 76–7253) with gram-positive bacteremia (P < .01). IL-6 levels increased before death in all 13 patients who died of sepsis. Median level was 7253 pg/mL (range, 445–95,906) within 3 days of death. Determination of IL-6 may be useful for early assessment and as a prognostic tool in leukocytopenic fever.]]></description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/171.1.225</identifier><identifier>PMID: 7798669</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adult ; Aged ; Agranulocytosis - chemically induced ; Agranulocytosis - complications ; Agranulocytosis - immunology ; Antibiotics ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Bacteremia ; Blood ; Chemotherapy ; Concise Communications ; Fever ; Fever - etiology ; Fever of unknown origin ; Fever of Unknown Origin - etiology ; Hodgkin Disease - drug therapy ; Humans ; Infections ; Interleukin-6 - blood ; Leukemia - drug therapy ; Lymphoma, Non-Hodgkin - drug therapy ; Middle Aged ; Myeloid leukemia ; Neutropenia ; Prognosis ; Sepsis ; Sepsis - diagnosis ; Sepsis - mortality</subject><ispartof>The Journal of infectious diseases, 1995-01, Vol.171 (1), p.225-228</ispartof><rights>Copyright 1995 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-cf94838ff36c8c4458e4242a257e4822f45850ae0e13737b7b2d7a22e4c3f0953</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30135425$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30135425$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7798669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tilman Steinmetz, H.</creatorcontrib><creatorcontrib>Herbertz, Annette</creatorcontrib><creatorcontrib>Bertram, Monika</creatorcontrib><creatorcontrib>Diehl, Volker</creatorcontrib><title>Increase In Interleukin-6 Serum Level Preceding Fever In Granulocytopenia And Correlation With Death From Sepsis</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description><![CDATA[Serum interleukin (IL)-6Ievels measured by ELISA were correlated with the clinical course of 53 adults with hematologic malignancies in 95 episodes of chemotherapy-induced leukocytopenia (< 1000/µL). The median IL-6 level was 15 pg/ml, (range, < 3–123) in 27 episodes without fever. This level was 14.5 pg/ml, (range, < 3–187) 72–48 h before onset of fever, 78 pg/mL (range, < 3–170) 24 h before fever in episodes with unexplained fever (FDO), and 182 pg/mL (range, 63–1076) 24 h before fever in episodes with positive blood cultures (P < .001). Within 24 h after onset of fever, median IL-6 level was 171 pg/ml, (range, 53–1134) in episodes of FDO, 444 pg/ml, (range, 38–7973) in episodes with gram-negative bacteremia, and 2017 pg/ml, (range, 76–7253) with gram-positive bacteremia (P < .01). IL-6 levels increased before death in all 13 patients who died of sepsis. Median level was 7253 pg/mL (range, 445–95,906) within 3 days of death. Determination of IL-6 may be useful for early assessment and as a prognostic tool in leukocytopenic fever.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Agranulocytosis - chemically induced</subject><subject>Agranulocytosis - complications</subject><subject>Agranulocytosis - immunology</subject><subject>Antibiotics</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Bacteremia</subject><subject>Blood</subject><subject>Chemotherapy</subject><subject>Concise Communications</subject><subject>Fever</subject><subject>Fever - etiology</subject><subject>Fever of unknown origin</subject><subject>Fever of Unknown Origin - etiology</subject><subject>Hodgkin Disease - drug therapy</subject><subject>Humans</subject><subject>Infections</subject><subject>Interleukin-6 - blood</subject><subject>Leukemia - drug therapy</subject><subject>Lymphoma, Non-Hodgkin - drug therapy</subject><subject>Middle Aged</subject><subject>Myeloid leukemia</subject><subject>Neutropenia</subject><subject>Prognosis</subject><subject>Sepsis</subject><subject>Sepsis - diagnosis</subject><subject>Sepsis - mortality</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUEtP3DAQtqoiukDvvVTyqbcsfsbJEW1ZWGkRraBqxcXyOpPWkNjBThD8ewy72kqjGc18D2k-hL5QMqek5qfOt41Lp1TROZ0zJj-gGZVcFWVJ-Uc0I4SxglZ1_QkdpXRPCBG8VIfoUKm6Kst6hoaVtxFMArzyuUaIHUwPzhclvoE49XgNT9DhHxEsNM7_xcu8xzfyRTR-6oJ9GcMA3hl85hu8CDFCZ0YXPP7txn_4O5jclzH02W9ILp2gg9Z0CT7v5jH6tTy_XVwW6-uL1eJsXVguxVjYthYVr9qWl7ayQsgKBBPMMKlAVIy1-SKJAQKUK642asMaZRgDYXlLasmP0bet7xDD4wRp1L1LFrrOeAhT0lQRziQjmUi2RBtDShFaPUTXm_iiKdFvIettyFlBNdU55Cz5uvOeNj00e8Eu1f_4fRpD3MOc0Pzbu77Y4i6N8LzHTXzQZX5G6ss_d1rV6upO_LzSt_wVpZiR2A</recordid><startdate>199501</startdate><enddate>199501</enddate><creator>Tilman Steinmetz, H.</creator><creator>Herbertz, Annette</creator><creator>Bertram, Monika</creator><creator>Diehl, Volker</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>199501</creationdate><title>Increase In Interleukin-6 Serum Level Preceding Fever In Granulocytopenia And Correlation With Death From Sepsis</title><author>Tilman Steinmetz, H. ; Herbertz, Annette ; Bertram, Monika ; Diehl, Volker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-cf94838ff36c8c4458e4242a257e4822f45850ae0e13737b7b2d7a22e4c3f0953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Agranulocytosis - chemically induced</topic><topic>Agranulocytosis - complications</topic><topic>Agranulocytosis - immunology</topic><topic>Antibiotics</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Bacteremia</topic><topic>Blood</topic><topic>Chemotherapy</topic><topic>Concise Communications</topic><topic>Fever</topic><topic>Fever - etiology</topic><topic>Fever of unknown origin</topic><topic>Fever of Unknown Origin - etiology</topic><topic>Hodgkin Disease - drug therapy</topic><topic>Humans</topic><topic>Infections</topic><topic>Interleukin-6 - blood</topic><topic>Leukemia - drug therapy</topic><topic>Lymphoma, Non-Hodgkin - drug therapy</topic><topic>Middle Aged</topic><topic>Myeloid leukemia</topic><topic>Neutropenia</topic><topic>Prognosis</topic><topic>Sepsis</topic><topic>Sepsis - diagnosis</topic><topic>Sepsis - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tilman Steinmetz, H.</creatorcontrib><creatorcontrib>Herbertz, Annette</creatorcontrib><creatorcontrib>Bertram, Monika</creatorcontrib><creatorcontrib>Diehl, Volker</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tilman Steinmetz, H.</au><au>Herbertz, Annette</au><au>Bertram, Monika</au><au>Diehl, Volker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase In Interleukin-6 Serum Level Preceding Fever In Granulocytopenia And Correlation With Death From Sepsis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1995-01</date><risdate>1995</risdate><volume>171</volume><issue>1</issue><spage>225</spage><epage>228</epage><pages>225-228</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract><![CDATA[Serum interleukin (IL)-6Ievels measured by ELISA were correlated with the clinical course of 53 adults with hematologic malignancies in 95 episodes of chemotherapy-induced leukocytopenia (< 1000/µL). The median IL-6 level was 15 pg/ml, (range, < 3–123) in 27 episodes without fever. This level was 14.5 pg/ml, (range, < 3–187) 72–48 h before onset of fever, 78 pg/mL (range, < 3–170) 24 h before fever in episodes with unexplained fever (FDO), and 182 pg/mL (range, 63–1076) 24 h before fever in episodes with positive blood cultures (P < .001). Within 24 h after onset of fever, median IL-6 level was 171 pg/ml, (range, 53–1134) in episodes of FDO, 444 pg/ml, (range, 38–7973) in episodes with gram-negative bacteremia, and 2017 pg/ml, (range, 76–7253) with gram-positive bacteremia (P < .01). IL-6 levels increased before death in all 13 patients who died of sepsis. Median level was 7253 pg/mL (range, 445–95,906) within 3 days of death. Determination of IL-6 may be useful for early assessment and as a prognostic tool in leukocytopenic fever.]]></abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>7798669</pmid><doi>10.1093/infdis/171.1.225</doi><tpages>4</tpages></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult Aged Agranulocytosis - chemically induced Agranulocytosis - complications Agranulocytosis - immunology Antibiotics Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Bacteremia Blood Chemotherapy Concise Communications Fever Fever - etiology Fever of unknown origin Fever of Unknown Origin - etiology Hodgkin Disease - drug therapy Humans Infections Interleukin-6 - blood Leukemia - drug therapy Lymphoma, Non-Hodgkin - drug therapy Middle Aged Myeloid leukemia Neutropenia Prognosis Sepsis Sepsis - diagnosis Sepsis - mortality |
| title | Increase In Interleukin-6 Serum Level Preceding Fever In Granulocytopenia And Correlation With Death From Sepsis |
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