l -Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis
Abstract Considering the pathologic importance of oxidative stress and altered lipid metabolism in osteoarthritis (OA), this study aimed to investigate the effect of l -carnitine supplementation on oxidative stress, lipid profile, and clinical status in women with knee OA. We hypothesized that l -ca...
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| Veröffentlicht in: | Nutrition research (New York, N.Y.) N.Y.), 2015-08, Vol.35 (8), p.707-715 |
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| creator | Malek Mahdavi, Aida Mahdavi, Reza Kolahi, Sousan Zemestani, Maryam Vatankhah, Amir-Mansour |
| description | Abstract Considering the pathologic importance of oxidative stress and altered lipid metabolism in osteoarthritis (OA), this study aimed to investigate the effect of l -carnitine supplementation on oxidative stress, lipid profile, and clinical status in women with knee OA. We hypothesized that l -carnitine would improve clinical status by modulating serum oxidative stress and lipid profile. In this randomized double-blind, placebo-controlled trial, 72 overweight or obese women with mild to moderate knee OA were randomly allocated into 2 groups to receive 750 mg/d l -carnitine or placebo for 8 weeks. Dietary intake was evaluated using 24-hour recall for 3 days. Serum malondialdehyde (MDA), total antioxidant capacity (TAC) and lipid profile, visual analog scale for pain intensity, and patient global assessment of severity of disease were assessed before and after supplementation. Only 69 patients (33 in the l -carnitine group and 36 in the placebo group) completed the study. l -Carnitine supplementation resulted in significant reductions in serum MDA (2.46 ± 1.13 vs 2.16 ± 0.94 nmol/mL), total cholesterol (216.09 ± 34.54 vs 206.12 ± 39.74 mg/dL), and low-density lipoprotein cholesterol (129.45 ± 28.69 vs 122.05 ± 32.76 mg/dL) levels compared with baseline ( P < .05), whereas these parameters increased in the placebo group. Serum triglyceride, high-density lipoprotein cholesterol, and TAC levels did not change significantly in both groups ( P > .05). No significant differences were observed in dietary intake, serum lipid profile, MDA, and TAC levels between groups after adjusting for baseline values and covariates ( P > .05). There were significant intragroup and intergroup differences in pain intensity and patient global assessment of disease status after supplementation ( P < .05). Collectively, l -carnitine improved clinical status without changing oxidative stress and lipid profile significantly in women with knee OA. |
| doi_str_mv | 10.1016/j.nutres.2015.06.003 |
| format | Article |
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We hypothesized that l -carnitine would improve clinical status by modulating serum oxidative stress and lipid profile. In this randomized double-blind, placebo-controlled trial, 72 overweight or obese women with mild to moderate knee OA were randomly allocated into 2 groups to receive 750 mg/d l -carnitine or placebo for 8 weeks. Dietary intake was evaluated using 24-hour recall for 3 days. Serum malondialdehyde (MDA), total antioxidant capacity (TAC) and lipid profile, visual analog scale for pain intensity, and patient global assessment of severity of disease were assessed before and after supplementation. Only 69 patients (33 in the l -carnitine group and 36 in the placebo group) completed the study. l -Carnitine supplementation resulted in significant reductions in serum MDA (2.46 ± 1.13 vs 2.16 ± 0.94 nmol/mL), total cholesterol (216.09 ± 34.54 vs 206.12 ± 39.74 mg/dL), and low-density lipoprotein cholesterol (129.45 ± 28.69 vs 122.05 ± 32.76 mg/dL) levels compared with baseline ( P < .05), whereas these parameters increased in the placebo group. Serum triglyceride, high-density lipoprotein cholesterol, and TAC levels did not change significantly in both groups ( P > .05). No significant differences were observed in dietary intake, serum lipid profile, MDA, and TAC levels between groups after adjusting for baseline values and covariates ( P > .05). There were significant intragroup and intergroup differences in pain intensity and patient global assessment of disease status after supplementation ( P < .05). Collectively, l -carnitine improved clinical status without changing oxidative stress and lipid profile significantly in women with knee OA.</description><identifier>ISSN: 0271-5317</identifier><identifier>EISSN: 1879-0739</identifier><identifier>DOI: 10.1016/j.nutres.2015.06.003</identifier><identifier>PMID: 26149189</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject><![CDATA[Ascorbic Acid - administration & dosage ; Benzothiazoles - blood ; Body Mass Index ; Carnitine - administration & dosage ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Clinical status ; Dietary Fats - administration & dosage ; Dietary Proteins - administration & dosage ; Dietary Supplements ; Double-Blind Method ; Energy Intake ; Female ; Gastroenterology and Hepatology ; Humans ; Knee osteoarthritis ; l-Carnitine ; Lipid Metabolism - drug effects ; Lipid profile ; Malondialdehyde - blood ; Middle Aged ; Motor Activity ; Nutrition Assessment ; Obesity - drug therapy ; Osteoarthritis, Knee - drug therapy ; Overweight - drug therapy ; Oxidative stress ; Oxidative Stress - drug effects ; Selenium - administration & dosage ; Sulfonic Acids - blood ; Thiobarbiturates - blood ; Triglycerides - blood ; Vitamin A - administration & dosage ; Vitamin E - administration & dosage ; Women ; Zinc - administration & dosage]]></subject><ispartof>Nutrition research (New York, N.Y.), 2015-08, Vol.35 (8), p.707-715</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-f9d4aca46bbadaf3c303c95555b20bfb3fa32079cfb3fa36a503b487a11768043</citedby><cites>FETCH-LOGICAL-c487t-f9d4aca46bbadaf3c303c95555b20bfb3fa32079cfb3fa36a503b487a11768043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.nutres.2015.06.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26149189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malek Mahdavi, Aida</creatorcontrib><creatorcontrib>Mahdavi, Reza</creatorcontrib><creatorcontrib>Kolahi, Sousan</creatorcontrib><creatorcontrib>Zemestani, Maryam</creatorcontrib><creatorcontrib>Vatankhah, Amir-Mansour</creatorcontrib><title>l -Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis</title><title>Nutrition research (New York, N.Y.)</title><addtitle>Nutr Res</addtitle><description>Abstract Considering the pathologic importance of oxidative stress and altered lipid metabolism in osteoarthritis (OA), this study aimed to investigate the effect of l -carnitine supplementation on oxidative stress, lipid profile, and clinical status in women with knee OA. We hypothesized that l -carnitine would improve clinical status by modulating serum oxidative stress and lipid profile. In this randomized double-blind, placebo-controlled trial, 72 overweight or obese women with mild to moderate knee OA were randomly allocated into 2 groups to receive 750 mg/d l -carnitine or placebo for 8 weeks. Dietary intake was evaluated using 24-hour recall for 3 days. Serum malondialdehyde (MDA), total antioxidant capacity (TAC) and lipid profile, visual analog scale for pain intensity, and patient global assessment of severity of disease were assessed before and after supplementation. Only 69 patients (33 in the l -carnitine group and 36 in the placebo group) completed the study. l -Carnitine supplementation resulted in significant reductions in serum MDA (2.46 ± 1.13 vs 2.16 ± 0.94 nmol/mL), total cholesterol (216.09 ± 34.54 vs 206.12 ± 39.74 mg/dL), and low-density lipoprotein cholesterol (129.45 ± 28.69 vs 122.05 ± 32.76 mg/dL) levels compared with baseline ( P < .05), whereas these parameters increased in the placebo group. Serum triglyceride, high-density lipoprotein cholesterol, and TAC levels did not change significantly in both groups ( P > .05). No significant differences were observed in dietary intake, serum lipid profile, MDA, and TAC levels between groups after adjusting for baseline values and covariates ( P > .05). There were significant intragroup and intergroup differences in pain intensity and patient global assessment of disease status after supplementation ( P < .05). Collectively, l -carnitine improved clinical status without changing oxidative stress and lipid profile significantly in women with knee OA.</description><subject>Ascorbic Acid - administration & dosage</subject><subject>Benzothiazoles - blood</subject><subject>Body Mass Index</subject><subject>Carnitine - administration & dosage</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Clinical status</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Energy Intake</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Knee osteoarthritis</subject><subject>l-Carnitine</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipid profile</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>Motor Activity</subject><subject>Nutrition Assessment</subject><subject>Obesity - drug therapy</subject><subject>Osteoarthritis, Knee - drug therapy</subject><subject>Overweight - drug therapy</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Selenium - administration & dosage</subject><subject>Sulfonic Acids - blood</subject><subject>Thiobarbiturates - blood</subject><subject>Triglycerides - blood</subject><subject>Vitamin A - administration & dosage</subject><subject>Vitamin E - administration & dosage</subject><subject>Women</subject><subject>Zinc - administration & dosage</subject><issn>0271-5317</issn><issn>1879-0739</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUs1u1DAQthCILoU3QMhHLgnjOIk3FyS04k-qxAE4W44z6Xrr2MF2tvQZeGkc0nLggi-2NN_PeL4h5CWDkgFr35xKt6SAsayANSW0JQB_RHZsL7oCBO8ekx1UghUNZ-KCPIvxBMAE4_wpuahaVnds3-3IL0uLgwrOJOOQxmWeLU7okkrGO2qmOfgzDlRb44xWlsZcWSK9Nenol0T1Ublr466p_2mGzDlnjbWpSJUbqDWzGWiWGI1Fahy99Vn7D5neOETqY0KvQjqG7B-fkyejshFf3N-X5PuH998On4qrLx8_H95dFbrei1SM3VArreq279WgRq45cN01-fQV9GPPR8UrEJ3enq1qgPeZqRgT7R5qfkleb7q5sx8LxiQnEzVaqxz6JUomgFf1Cs7QeoPq4GMMOMo5mEmFO8lArjHIk9xikGsMElqZY8i0V_cOSz_h8Jf0MPcMeLsBMP_zbDDIqA06jYMJqJMcvPmfw78CDxHd4B3Gk1-CyzOUTMZKgvy6rsK6CazJW8BFxX8DxOm0WQ</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Malek Mahdavi, Aida</creator><creator>Mahdavi, Reza</creator><creator>Kolahi, Sousan</creator><creator>Zemestani, Maryam</creator><creator>Vatankhah, Amir-Mansour</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>l -Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis</title><author>Malek Mahdavi, Aida ; Mahdavi, Reza ; Kolahi, Sousan ; Zemestani, Maryam ; Vatankhah, Amir-Mansour</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-f9d4aca46bbadaf3c303c95555b20bfb3fa32079cfb3fa36a503b487a11768043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Ascorbic Acid - administration & dosage</topic><topic>Benzothiazoles - blood</topic><topic>Body Mass Index</topic><topic>Carnitine - administration & dosage</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Clinical status</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Energy Intake</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Knee osteoarthritis</topic><topic>l-Carnitine</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipid profile</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>Motor Activity</topic><topic>Nutrition Assessment</topic><topic>Obesity - drug therapy</topic><topic>Osteoarthritis, Knee - drug therapy</topic><topic>Overweight - drug therapy</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Selenium - administration & dosage</topic><topic>Sulfonic Acids - blood</topic><topic>Thiobarbiturates - blood</topic><topic>Triglycerides - blood</topic><topic>Vitamin A - administration & dosage</topic><topic>Vitamin E - administration & dosage</topic><topic>Women</topic><topic>Zinc - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malek Mahdavi, Aida</creatorcontrib><creatorcontrib>Mahdavi, Reza</creatorcontrib><creatorcontrib>Kolahi, Sousan</creatorcontrib><creatorcontrib>Zemestani, Maryam</creatorcontrib><creatorcontrib>Vatankhah, Amir-Mansour</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition research (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malek Mahdavi, Aida</au><au>Mahdavi, Reza</au><au>Kolahi, Sousan</au><au>Zemestani, Maryam</au><au>Vatankhah, Amir-Mansour</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>l -Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis</atitle><jtitle>Nutrition research (New York, N.Y.)</jtitle><addtitle>Nutr Res</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>35</volume><issue>8</issue><spage>707</spage><epage>715</epage><pages>707-715</pages><issn>0271-5317</issn><eissn>1879-0739</eissn><abstract>Abstract Considering the pathologic importance of oxidative stress and altered lipid metabolism in osteoarthritis (OA), this study aimed to investigate the effect of l -carnitine supplementation on oxidative stress, lipid profile, and clinical status in women with knee OA. We hypothesized that l -carnitine would improve clinical status by modulating serum oxidative stress and lipid profile. In this randomized double-blind, placebo-controlled trial, 72 overweight or obese women with mild to moderate knee OA were randomly allocated into 2 groups to receive 750 mg/d l -carnitine or placebo for 8 weeks. Dietary intake was evaluated using 24-hour recall for 3 days. Serum malondialdehyde (MDA), total antioxidant capacity (TAC) and lipid profile, visual analog scale for pain intensity, and patient global assessment of severity of disease were assessed before and after supplementation. Only 69 patients (33 in the l -carnitine group and 36 in the placebo group) completed the study. l -Carnitine supplementation resulted in significant reductions in serum MDA (2.46 ± 1.13 vs 2.16 ± 0.94 nmol/mL), total cholesterol (216.09 ± 34.54 vs 206.12 ± 39.74 mg/dL), and low-density lipoprotein cholesterol (129.45 ± 28.69 vs 122.05 ± 32.76 mg/dL) levels compared with baseline ( P < .05), whereas these parameters increased in the placebo group. Serum triglyceride, high-density lipoprotein cholesterol, and TAC levels did not change significantly in both groups ( P > .05). No significant differences were observed in dietary intake, serum lipid profile, MDA, and TAC levels between groups after adjusting for baseline values and covariates ( P > .05). There were significant intragroup and intergroup differences in pain intensity and patient global assessment of disease status after supplementation ( P < .05). Collectively, l -carnitine improved clinical status without changing oxidative stress and lipid profile significantly in women with knee OA.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26149189</pmid><doi>10.1016/j.nutres.2015.06.003</doi><tpages>9</tpages></addata></record> |
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| subjects | Ascorbic Acid - administration & dosage Benzothiazoles - blood Body Mass Index Carnitine - administration & dosage Cholesterol, HDL - blood Cholesterol, LDL - blood Clinical status Dietary Fats - administration & dosage Dietary Proteins - administration & dosage Dietary Supplements Double-Blind Method Energy Intake Female Gastroenterology and Hepatology Humans Knee osteoarthritis l-Carnitine Lipid Metabolism - drug effects Lipid profile Malondialdehyde - blood Middle Aged Motor Activity Nutrition Assessment Obesity - drug therapy Osteoarthritis, Knee - drug therapy Overweight - drug therapy Oxidative stress Oxidative Stress - drug effects Selenium - administration & dosage Sulfonic Acids - blood Thiobarbiturates - blood Triglycerides - blood Vitamin A - administration & dosage Vitamin E - administration & dosage Women Zinc - administration & dosage |
| title | l -Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis |
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