Effect of rovatirelin, a novel thyrotropin-releasing hormone analog, on the central noradrenergic system

Rovatirelin ([1-[-[(4S,5S)-(5-methyl-2-oxo oxazolidin-4-yl) carbonyl]-3-(thiazol-4-yl)-l-alanyl]-(2R)-2-methylpyrrolidine) is a novel synthetic agent that mimics the actions of thyrotropin-releasing hormone (TRH). The aim of this study was to investigate the electrophysiological and pharmacological...

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Veröffentlicht in:	European journal of pharmacology 2015-08, Vol.761, p.413-422
Hauptverfasser:	Ijiro, Tomoyuki, Nakamura, Kayo, Ogata, Masanori, Inada, Hiroyuki, Kiguchi, Sumiyoshi, Maruyama, Kazuyasu, Nabekura, Junichi, Kobayashi, Mamoru, Ishibashi, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Administration, Oral Adrenergic Neurons - drug effects Adrenergic Neurons - metabolism Animals Dose-Response Relationship, Drug Ligands Locomotor activity Locus coeruleus Locus Coeruleus - cytology Locus Coeruleus - drug effects Locus Coeruleus - metabolism Male Microdialysis Motor Activity - drug effects Noradrenaline Norepinephrine - metabolism Oxazolidinones - administration & dosage Oxazolidinones - metabolism Oxazolidinones - pharmacology Prefrontal Cortex - cytology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Protein Binding Proto-Oncogene Proteins c-fos - metabolism Pyrrolidines - administration & dosage Pyrrolidines - metabolism Pyrrolidines - pharmacology Radioligand Assay Rats, Sprague-Dawley Rats, Wistar Receptors, Thyrotropin-Releasing Hormone - agonists Receptors, Thyrotropin-Releasing Hormone - metabolism Rovatirelin Thyrotropin-releasing hormone (TRH) Thyrotropin-Releasing Hormone - administration & dosage Thyrotropin-Releasing Hormone - analogs & derivatives Thyrotropin-Releasing Hormone - metabolism Thyrotropin-Releasing Hormone - pharmacology Time Factors TRH analog
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